What Is the Recommended Resveratrol Dosage?

Resveratrol is a non-flavonoid polyphenolic compound that is an antitoxin produced by many plants when stimulated. It can be synthesized in grape leaves and grape skins, and is a biologically active ingredient in wine and grape juice. It is easily absorbed orally and excreted in urine and feces after metabolism. In vitro and animal experiments show that resveratrol has anti-oxidant, anti-inflammatory, anti-cancer and cardiovascular protection effects. ^[1] Resveratrol is not a medicine, and there is insufficient evidence to suggest that resveratrol is good for the human body. ^[2-3]

Resveratrol was discovered as early as 1924, and was first isolated from the roots of Veratrum grandiflorum by the Japanese in 1940. ^[4]

Resveratrol has a relatively low bioavailability in the body. Studies have shown that the bioavailability of resveratrol metabolites in the small intestine and liver is about 1%. Resveratrol is rapidly metabolized in animals and peaks in plasma within 5 minutes. Animal metabolism studies have found that resveratrol is mainly metabolized in the form of resveratrol sulfate and glucuronidation products in mammals such as rats, pigs and dogs. Studies have shown that resveratrol is distributed in different tissues of mammals in a combined form, and resveratrol is more absorbed and distributed in organs rich in blood flow, such as liver, kidney, heart and brain. A study of the metabolism of resveratrol in the human body found that the concentration of resveratrol in the plasma of normal humans showed a "double-peak phenomenon" after oral administration, but this phenomenon was not observed after IV administration (intravenous injection); Alcohol metabolites are mainly glucuronidation and sulfation. Patients with colorectal cancer received oral resveratrol, the left colon absorption was lower than that on the right, and six metabolites resveratrol-3-O-glucuronide and resveratrol-4-O-glucose were obtained. Resveratrol sulfate and glucuronide compounds such as uronic acid, resveratrol-3-O-sulfate, and resveratrol-4'-O-sulfate. ^[7]

Resveratrol and its derivatives are mainly present in at least 72 plants in 21 families and 31 genera, including Vitis, Polygonum, Peanut, Veratrum, etc., including

Resveratrol is not high in nature, and can be transformed by various methods. ^[5]

Due to the special biological activity of resveratrol, its development and utilization have been deepened, and it has been widely used in food processing, health care industry and medicine. In terms of health care, in 2010, North America Corporation launched the first anti-aging beverage called Nutra Resveratrol, which is called "the most functional beverage in the world". The natural plant extract VIVIX from Shaklee in the United States is rich in resveratrol active ingredients and has a strong resistance to cellular aging. It is known as the "21st century anti-aging holy product". In recent years, some resveratrol products have appeared in China, such as "Jinruifen Capsules" in Xi'an, "Kunmeiliang Brand Resveratrol Capsules" in Beijing, and "Tiens Vitality Kangkang Capsules" in Tianjin, etc. It has been widely used in various fields such as food additives, beverages and cosmetics. ^[5]

Although the biological activity of resveratrol has been basically recognized worldwide, there are still many problems in the research and development of resveratrol products. ^[5]

In terms of raw materials, Polygonum cuspidatum's main resource, Polygonum cuspidatum, is concentrated in Hunan and Sichuan, and the annual mining volume has reached saturation. Although research on artificial cultivation of Polygonum cuspidatum has started, due to the supply of technology and wild resources, and the cost of cultivation Other reasons have not been planted in large areas. At this stage, the natural wild resources of resveratrol are scarce, which has formed a huge gap with market demand. ^[5]

In terms of quality control, there are relatively few researches on the identification of the true attributes of the source of resveratrol, and a complete set of laws and regulations on quality control of resveratrol has not been formulated. Therefore, there are certain defects in management control. Chinese traditional medicine Polygonum cuspidatum is an extremely important raw material for industrial production of resveratrol. The yield of resveratrol is high, but the nature of the medicinal materials is difficult to be recognized in the international market. The content of resveratrol in grapes is very low, but because of its safety and non-toxicity, long history of consumption and better biological activity, it has become an important raw material for the most popular resveratrol natural health products. In the international market, the price of resveratrol extracted from grapes as a raw material is much higher than that of resveratrol derived from traditional Chinese medicine Polygonum cuspidatum. The price of its products varies greatly and is driven by market interests. The fact that cheap Polygonum cuspidatum resveratrol counterfeits the expensive grape resveratrol and is used in various fields such as health products and foods, which causes consumers' physical health to be threatened to some extent, and also causes trade disputes to varying degrees. This puts forward higher requirements for the quality control of resveratrol. ^[5]