What is the treatment of methanol poisoning?
Methanol poisoning usually involves removal and neutralization of methanol still in the stomach, neutralizing metabolic acidosis and preventing the remaining methanol and removal of non -metabolized methanol and the remaining methanol metabolites. When methanol is used, the body breaks the compound into toxic parts or metabolites that cause metabolic acidosis, and blood and other body fluids become highly acidic. Metabolic acidosis can be fatal if it is not treated quickly.
If the patient is discovered soon after ingestion of methanol, the team may still perform a rapid effect to remove any methanol in the stomach by inductioning or exhausting poison. Activated coal, a relatively universal poisonous neutralizer, can also be administered by conscious and willing patients through a drink or patients with unconsciousness after intubation to protect the lungs. Activated coal absorbs methanol, is not digestuded with stomach, passes through the intestinal tract and iseliminated. Any methanol that was cleaned with a stomach or reached the digestive tract before drawing the stomach and activated treatment on coal, will break and begin to poison the body.
The second stage of treatment of methanol poisoning is the neutralization of metabolic acidosis caused by metabolism of methanol to antic acid. The diagnosis of metabolic acidosis is difficult unless methanol poisoning is suspicious because the symptoms are relatively general and include vomiting, chest pain, heart palpitations and anxiety mental state. Treatment begins by performing arterial blood gas for testing the body level or how acidic is blood, and the level of bicarbonate or the ability of the blood buffer against increased acid levels. Sodium sodium bicarbonate is administered to neutralize the elevated ph and folinic acid or folic acid to help metabolize formic acid. PatientIntravenous fluids and electrolytes, airway control and will be evaluated and treated for existing neurological or cardiovascular problems resulting from methanol poisoning will often be administered.
In the third phase of treatment, the aim is to prevent further metabolism of methanol and remove non -metabolized methanol and the remaining toxic metabolites. Alcohol dehydrogenases are enzymes that catalyze the decomposition of alcohols and, in the case of methanol poisoning, allow the methanol of antic acid to be disintegrated. Ethanol or fomepizol are usually given to prevent metabolism of methanol because it acts as competing inhibitors on alcohol dehydrogenases, which means they bind to alcohol dehydrogenases and leave them inactive and unnecessary. As a result, ethanol or fomepizol prevents or slows metabolism of methanol to its toxic sets, which enable to eliminate methanol by the kidneys. Hemodialysis will also be performed to keep blood of any methanol and antic acid.