What Is a Bence Jones Protein?

This week's protein is also called Ben-week protein, Ben Jones protein, Bence-Jones protein (BJP). globulin. It often appears in the urine of patients with myeloma and has diagnostic significance.

Protein of the week

Right!

This week's protein is also known as Ben-week protein, Ben Jones protein, and Bence-Jones protein (BJP).

There are two types of immunoglobulin light chains: kappa light chain and lambda light chain. The free light chain is also known as this week protein (BJP).

(BJP)

The presence of this protein in urine reflects the light chain portion of malignant plasma cells that produce a large number of clonal immunoglobulins.

Urine weekly protein (BJP) normal value

Qualitative: negative. Newborns can be weakly positive.

Clinical significance of urine week protein (BJP)

Positive: Multiple myeloma patients produce a large amount of protein this week, and the positive rate can reach 35% to 65%. The amount of protein this week reflects the number of monoclonal cells producing this week's protein, which is meaningful for observing the course of myeloma and judging the effect of chemotherapy. Protein positives this week are also seen in benign monoclonal immunoglobulinemia, macroglobulinemia, amyloidosis, malignant lymphoma, chronic nephritis, and metastatic cancer. Ingestion of drugs such as aminosalicylic acid, chlorpromazine, and high-dose penicillin can cause false positives. Alkaline urine, severe urethral infections, etc. can appear false negative.

Note: For the determination of Zhou-zhou protein, only fresh urine specimens need to be taken according to the conventional method, and it is only meaningful to measure this when the urine protein is qualitatively slightly positive. If urine protein is qualitatively negative, Ben-Chou protein is also negative.