What is a chimeric antibody?
A chimeric antibody is an antibody made by a combination of genetic material from a non -luminous source such as a mouse, with a genetic material from a human being. Chimeric antibodies are generally about two -thirds of humans, which reduces the risk of reaction to foreign antibodies from an inhumane animal when used in therapeutic treatment. A closely related concept is a humanized antibody, produced in a similar way, but contains closer 90% of human genetic material. Using technology, people can cut and combine genetic material from multiple sources and combine it together. The chimeric antibody contains antibodies developed by animal cells in culture, with genetic code slices replaced by human genes to solve concerns about the potential reaction with the animal's genetic material.
Several Basid on Chimeric antibodies have been approved for human use and many others are in development. These compounds take the form of monoclonal antibodies, antibodies produced by cloningM parental cells to achieve a constant and reliable source of antibodies for use in the treatment of diseases such as cancer. Medicles made of chimeric antibodies have an extension -ximab. Humanized antibodies are identified with the suffix -zumab. This nomenclature is designed to facilitate the distinction of the origin of the drug.
In the production of monoclonal antibodies, animals are vaccinated by the required antigen and stimulate them to produce antibodies. The cells are harvested and grown in culture where they are associated with multiple myeloma cells. The fused cells expresses various antibodies and people can choose cells producing the desired antibody, clean them and grow them in culture to produce monoclonal antibodies, purified antibodies produced by a single parent cell. To create a chimeric antibody, during the cell cultivation process in culture is used by complicated technology and cleaning the desireof the cells.
Monoclonal antibodies sometimes cause side effects or are less effective because the patient's body reacts to foreign DNA from an animal used to produce antibodies. Chimeric antibody solves this problem by eliminating some of the animal DNA, reducing chances to reaction and humanized antibodies contain an even lower risk of side effects. Such drugs have a number of potential applications in the treatment of the disease, as they can be developed to focus on very specific antigens associated with patients or infectious cells, with other cells left in the body itself.