What Is a Paraprotein?

Hypersensitive C-reactive protein (hs-CRP) is a C-reactive protein in plasma, also known as high-sensitivity C-reactive protein. The clinical guidance of high-sensitivity C-reactive protein is mainly manifested in cardiovascular disease, neonatal bacterial infection, and kidney transplantation.

High-sensitivity C-reactive protein

hs-CRP High-sensitivity C-reactive protein is a clinical laboratory using ultra-sensitive detection technology, which can accurately detect low-concentration C-reactive protein, improve the sensitivity and accuracy of the test, and is a sensitive indicator for distinguishing low-level inflammatory states. Serum hs -CRP level vs.

Studies have shown that in elderly patients with acute cerebral infarction, the prognosis of patients with elevated CRP is poor; hs-CRP content is related to the infarct size and the degree of neurological deficits, and is one of the indicators of the degree of pathological changes in patients with cerebral infarction. The pathological process of thrombosis and arteriosclerosis is one of the risk factors for stroke. The inflammatory response of atherosclerotic plaques is an important cause of plaque rupture and instability. During the formation of atherosclerotic plaques, CRP, complement complexes and foam cells are deposited in the arterial wall. Lipoprotein binding, activates the complement system, generates a large number of inflammatory mediators, releases oxygen free radicals, causes endometrial damage, vasospasm, and unstable plaque shedding, exacerbates atherosclerosis caused by stenosis and ACI. Increasing evidence shows that low levels of CRP are closely related to other risk factors for cardiovascular disease, such as hypertension and hyperlipidemia; at the same time, elevated CRP can increase the incidence of heart disease and stroke in patients with hypertension; Therefore, CRP is a pro-inflammatory factor related to the occurrence, evolution and development of atherosclerosis. Epidemiological investigations also show that people with elevated hs-CRP levels are twice as likely to have an acute stroke as normal healthy people, and three times more likely to have a heart attack than normal. The 2003 European Guidelines for the Prevention and Treatment of Hypertension (ESH / ESC) formally recommended that hs-CRP levels be measured in patients with hypertension.