What is angiotensinogen?

Angiotensinogen is a precursor of protein and hormone involved in the Renin-English system system (RAAS), which causes an increase in blood pressure. It is produced in the liver and is excreted in the bloodstream, where it acts as a substrate for the Renin enzyme. It is a serum globulin alpha-2, a type of globular protein found in the bloodstream and is usually polar. Unlike other proteins in this category, angiotensinogen has no inhibitory effect on other enzymes. Although angiotensinogen has more than 450 amino acids, depending on the species, only the first 12 at the end of the nitrogen (n-terminal) ends are important in the way. Only the first 10 is removed by Renin to form ai. While AI and angiotensinogen have a small or no effect on the body, AII stimulates thirst in the brain, increases blood pressure by reducing the blood vessels and signals the release of vasopressin and aldosterone. VaSopresin increases the retention of water in the kidneys, while aldosterone increases the retention of salt. Both increase the volume of fluid in the bloodstream and increase blood pressure.

AIII is further clenched to form angiotensin III (AIII), a seven amino acid peptide and later angiotensin IV (aIV), six-amino acid peptide, various enzymes of angiotensinase in the blood. AIII and AIV have similar effects in the body as AII, but are less effective. As a result, they are important in the break -up of AII and the end of RAAS.

previouslyaii, AII, also provides positive feedback and increases the production of angiotensinogen in the liver. Other hormones and molecules that increase production include estrogen, thyroid hormones and plasma corticosteroid. Estrogen and AII's scattering can also create a change in blood pressure that fluctuates with the menstrual cycle of a woman. Aldosterone levels usually increase during luteal phase CYKLU, which could worsen the symptoms of retention and bloating fluids.

Raas was a key interest in the study of hypertension. Angiotensinogen is a precursor molecule and renin substrate, so the study focused on it as a potential indicator of hypertension. Scientists have found strong links between essential hypertension and angiotensinogen gene for most ethnicities. However, it was not found that the Chinese were experiencing this connection.