What Is an Autoantibody?

Autoantibodies are antibodies directed to their own tissues, organs, cells, and cellular components. Normal human blood can have low titers of autoantibodies. If the titer of autoantibodies exceeds a certain level, it may cause damage to the body and induce disease. . There are many autoantibodies in autoimmune diseases, the most important of which is antinuclear antibodies.

Autoantibodies

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Autoantibodies refer to their own tissues, organs,

Autoantibodies are antibodies directed against their own tissues, organs, cells, and cellular components. The growth, development and survival of the human body are maintained by a complete autoimmune tolerance mechanism.

Antibodies are generally produced by the immune system after foreign proteins or other substances (especially pathogenic bacteria) enter the body.

antibody	Related diseases
Anti-duplex DNA	Systemic lupus erythematosus
Anti-exosome complex	Sclerosing myositis
Anti-Ro or La protein	Systemic lupus erythematosus, infant atrioventricular block, primary sjogren's syndrome
Anti-Smith antigen	Systemic lupus erythematosus
Antiphospholipid	Antiphospholipid syndrome
Anti-single-chain annealing protein or single-chain binding protein	Sjogren's syndrome
Anti-neutrophil cytoplasm (c-ANCA)	Wegener's granuloma
Anti-neutrophil perinuclear (p-ANCA)	Microscopic polyangiitis, Churg-Strauss syndrome, systemic vasculitis (non-specific), nodular polyarteritis (not confirmed)
Anti-IgG (rheumatoid factor)	Rheumatoid arthritis
Anticentromere	scleroderma
Anti-topoisomerase	scleroderma
Anti-smooth muscle	Chronic autoimmune hepatitis
Antimitochondria	Primary biliary cirrhosis
Anti-nicotinic acetylcholine receptor	Myasthenia gravis
Anti-voltage-gated calcium channel	Lambert-Eaton syndrome
Anti-thyroid peroxidase (microsomal)	Hashimoto's thyroiditis
Anti-TSH receptor	Graves disease
Anti-Hu protein	Paraneoplastic cerebellar syndrome
Anti-voltage-gated potassium channel (VGKC)	Limbic encephalitis
Anti-N-methyl-D-aspartate receptor (NMDA)	encephalitis