What is apoptosis inhibitor?

Apoptose protein inhibitor, or IAP, is a type of protein that is able to stop apoptosis or programmed cell death. Programmed cellular death is an important process in the development, immune defense and cancer protection, but must be regulated to avoid uncontrolled cellular death. In general, apoptosis inhibitor will function inhibiting caspase, proteins that are necessary to start apoptosis. They also regulate some transcription factors that are important for the synthesis of various proteins that lead to apoptosis. It is believed that apoptosis inhibitors may be related to the formation of a tumor, because one of the characteristics of many cancer cells is the inability to undergo apoptosis.

Caspases are primary proteins involved in the initiation of apoptosis, so that naturally they are the primary objectives of almost every apoptosis inhibitor. Different caspases work in different ways; Caspases of initiators are necessary to activate effector caspaseThey were apoptosis. Apoptosis inhibitor may disrupt every stage of this process, stopping the process of programmed cellular death. Although there are many types of IAP, their structures are very similar and work through very similar mechanisms.

There are also regulatory proteins that exist for the regulation of apoptosis inhibitors. For example, the second Caspase or SMAC derived from mitochondria is bound to an inhibitor of apoptosis protein in order to increase caspase activity, thus promoting apoptosis. Complicated and overlapping mechanisms of regulation of apoptosis are essential because unregulated or completely inhibited apoptosis can be very harmful to the organism's health. It is important to ensure that beneficial and healthy cells are not unnecessarily destroyed and that harmful or undezzable cells are removed before their complete effects will be felt. For this reason it is also important to reThe gulatory factors were subject to regulation because they are primary determinants of apoptosis.

It is possible that apoptosis inhibitor may have a role in cancer, because cancer cells are not subject to apoptosis, as the damaged or mutated cells should otherwise. Much of the evidence for this theory comes from the inhibitor of apoptosis protein called Survivin, which is highly predominant in almost all human tumors. It has been shown that the inhibitor of this apoptosis inhibitor leads to a reduction in the size of some tumors because its absence opens the path to apoptosis so that cancer cells can undergo programmed cell death.