What is involved in the production of plates?
The presence of a growth factor called thrombopietin (TPO) is generally needed before the plate is produced. TPOs are mostly produced by the liver and kidneys when blood plate levels are low. This in turn stimulates bone marrow to produce megakaryocytes that are responsible in the production of plates. The plates are technically released when megakaryocytes undergo fragmentation. They are small cells that do not contain nucleus or have a certain shape. Each plate has a lifetime of about 12 days in the bloodstream since they were released from megacaryocytes. When there is an injury in blood vessels, platelets often follow the damaged place and collect to create what is generally known as a plug of plates. There are other important processes such as a coagulation cascade that technically lead to a stable blood clot.
Problems usually arise if they are in the blood abnorMalter of platelet levels. The low number of plates or thrombocytopenia occurs when the production of pads occurs, as seen in some viral infections and after exposure to chemicals and radiation. The production of plates can also be influenced by vitamin B12 deficiency, lack of folate and disease affecting bone marrow. Another factor that often causes thrombocytopenia is increased destruction of plates. This destruction could occur after the exposure to the serpentine poison, in the presence of the syndrome obtained by immune deficiency (AIDS), with disseminated lupus erythematosus, or after response to blood transfusion.Several inherited genetic diseases that can cause the inserts to perform, haemophilia and AB and von Willebrand's disease. Insert coagulation factors are often missing or have a very low blood level since birth. Individuals with haemophilia and von Willebrand disease generally tend to bleed from cuts and tooth extraction. Some may even suffer VNIts bleeding. Treatment of plates in the form of platelets is sometimes recommended in some haemophilles.
thrombocytosis or high number of inserts is observed in increased plate production that occurs under many conditions. Examples include vera polycythema, chronic myelogenic leukemia, necessary thrombocytosis, liver cirrhosis and inflammatory bowel diseases. A high number of inserts often do not have symptoms and symptoms, but sometimes it may promote thrombosis or the formation of a clot inside the blood vessels.
When taking drugs, an increased risk of bleeding may occur. Some prescription drugs and over-the-counter medicines that may affect the function of the plates are aspirin, non-steroidal-inflammatory drugs (NSAIDs), antibiotics, diuretics, antihistamines and anticoagulants. Plate production drugs include chloramphenicol and many drugs used in the treatment of cancer.