What is the coagulation system?
2 This complex process is referred to as haemostasis. The coagulation system consists of three main components: endothelium, platelets and coagulation proteins. When injured occurs, they threaten the integrity of the pressure circulation system, these components interact and create blood clots in the damage source. Endangered coagulation systems may be the result of disorders affecting the ability of blood to either produce clotting, such as haemofelia and von Willebrand's disease, or prevent unnecessary clotting, called thrombotic disorders. Inserts are connected to damaged endothelial cells, forming and plug of plates. The coagulation process produces thrombin, which leads to long -term stabilization of pads with fibrin springs and creates a clot. The clot expansion is controlled by anticoagulants produced in endothelial cells.
Endothelial cells are one of the three primary components of the coagulation system. These cells are responsible for starting coagulation and restricting it to the wound site. Without these bGenuine would fail or completely collide in the blood vessels of the body if necessary.
It is located in the inner walls of the blood vessels, the endothelial cells perform its homeostatic function by the production and storage of von Willebrand Factor (VWF). This large protein acts as an adhesive that holds each other and on the cell matrix around the wound site. Endothelial cells also synthesize a protein called FEREC tissue, which is involved in the production of thrombin, the main agent in coagulation.
Anticoagulance function is also operated by endothelial cells through their production of tissue factor inhibitor (TFPI) and prostacyclin. TFPI inhibits the tissue factor complex and prevents the formation of thrombin. Prostacycline inhibits the aggregation of plates. Together, these anticoagulant agents maintain the fluency of the circulatory system and limit the range of precipitation.
Plates are the second main part of the coagulation SYstool. Plates, also called platelets, are small, indispensable, cytoplasmic fragments that are freely flowing on the blood vessels of the body. Created in the bone marrow, plates contain various receptors that allow them to connect together and damage endothelial cells at the wound site. They are held together by von Willebrand Factor and create a plug of plates.
coagulation proteins form the third main component of the coagulation system. These proteins lead to the formation of fibrin springs that grow into blood clots. There are 14 main coagulation proteins, including prothrombin, fibrinogen and tissue factor. Protrombin and tissue factor is combined in a complex process to form a thrombin, a primary reagent in coagulation. Each aspect of haemostasis is involved in careful control in circulation.