What is Philadelphia chromosome?
Philadelphia chromosome is a chromosomal abnormality that can lead to leukemia. This abnormality is most closely associated with myelogenic leukemia, although it may be present in patients with other leukemi. Testing, which reveals the presence of Philadelphia chromosome, can be used to determine the best course of treatment with leukemia.
This abnormality arises as a result of a problem in cell division in the bone marrow. It is a type of translocation, which means that the genetic material of two different chromosomes switches. In this particular abnormality, nine and 22 chromosomes are involved. Only one bone marrow cell with this abnormality for leukemia development is sufficient because the cell replicates itself and maintains abnormality, eventually causing problems with the production of myelogenic blood cells. She paved the way to many future discoveries as soon as people understood how the translocation occurred and what he did.This discovery also changed access to the treatment of myelogenic leukemia.
Theoretically, medicines can be developed that can focus on Philadelphia chromosome, allowing the oncologist to supply targeted doses of cancer drugs to kill dishonest cells. Since 2009, several experimental drugs have developed, and cancer scientists have tried to improve and develop therapeutic protocols. At some point, these drugs may allow the pain and risk of bone marrow transplantation in the treatment of myelogenic leukemia.
When patients are diagnosed with leukemia, genetic testing is often recomked to learn more about the origin of cancer and because the understanding of cancer genetics can help doctors to determine the best treatment. Patients with Philadelphia chromosom Positive myelogenic leukemia will have a therapeutic approach that differs from patients who lack abnormality, and the same appliesFor people with other leukemi who test positive to this abnormality.
Philadelphia chromosome cannot be handed over to offspring because it is an abnormality that occurs during cell division, and is present only in the bone marrow, not in germ cells that dictate genetic inheritance. However, genetic testing can reveal the presence of other abnormalities that can play a role in inheritance, which is important to talk to a genetic advisor about the results of any type of genetic testing.