What are some derivatives of Coumarin?

Coumarin derivatives are widely used in pharmaceutical and commercial applications for their health properties. The compound found naturally in plants such as beans Tonka, cinnamon, sweet clover and vanilla grass has several chemical derivatives that can be found naturally or synthesized in the laboratory. These include naturally occurring umbelliferon, as well as synthetic drugs Warfarin and Bishydroxycoumarin. Cumarin derivatives have been shown to have anti -inflammatory and anticoagulant properties, but can also be toxic in large quantities and are sometimes used as a genitals.

Although Coumarin does not work in itself as an anticoagulant-liner that can be chemically modified, it does not work to work. Coumarin molecule changes by adding certain chemical groups to a substance called 4-hydroxycoumarin, which can in turn be transformed into drugs for sandicoagulant properties. There are several different forms of 4-hydroxycoumarins.When a sweet clover interacts with mushrooms and becomes moldy, it undergoes a chemical change that causes cumarin to transform into bishydroxycoumarin in the plant. The anticoagulant properties of commarin derivatives, such as dicoumarol, were first discovered in 1939 of evidence that cattle in North America, which was a fed with a sweet clover, suffered from bleeding or bleeding. Bishydroxycoumarin was later made synthetically for use as an oral anticoagulant.

Warfarin, a Dicoumarol derivative, is a popular synthetic drug used to prevent blood clots in cases where the formation of a clot could reduce blood supply to an important organ such as heart or brain. Before his nine, the drug was commonly used as an anticoagulant as an anticoagulant. Warfarin and other Coumarin derivatives function as pesticides by causing uncontrolled bleeding in the target animal.

AnticoaguHandling activity of cumarin derivatives can be toxic to humans if these compounds are used in excessive quantities. Vitamin K is a well -known antidote in cases where excessive ingestion occurred. This is because substances such as Dicoumarol function, inhibition of vitamin K production in the production of prothrombin, the necessary compounds in the process of blood clotting. Adding vitamin K can be counted against vitamin K.

Umbelliferone, unlike warfarin and other synthetic compounds, can be found naturally in certain fruits. It also has healing properties, including antioxidant activity. In other words, this can help prevent oxidation, a chemical reaction that can lead to cell destruction. Umbelliferone is useful as an addition to sunscreen and as a starting point for synthesizing anti -cancer drugs.