What Is Alpha Oxidation?

Biological terms. Refers to oxidation on -carbon, a way of fatty acid degradation. Alpha-oxidation can occur on free fatty acids. This process does not produce ATP, and it can occur on the endoplasmic reticulum or on mitochondria or peroxisomes.

-oxidation

Alpha-oxidation is a method of fatty acid degradation, but
The following uses phytanic acid as an example to explain the process of -oxidation (this process is considered to be performed entirely in the peroxisome).
Phytanic acid and its precursor phytanol are abundantly present in the human diet, so alpha-oxidation is very important in the body. However, patients with a type of Refsum's disease have a congenital lack of alpha-
Casteels, M; Foulon; Mannaerts; Van Veldhoven, Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence, European journal of biochemistry / FEBS. 2003, 270 (8): 16191627, PMID12694175Quant, Patti A. ; Eaton, Simons., Current views of fatty acid oxidation and ketogenesis: from organelles to point mutations, 466. 2nd, New York, NY: Kluwer Acad./Plenum Publ .. 1999: 292295, ISBN0306462001

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