What Is Caffeic Acid?

Caffeic acid, molecular formula C9H8O4, molecular weight 180.15, is a yellow crystal obtained from a concentrated aqueous solution and a monohydrate from a dilute aqueous solution. Decomposition point 223 225 ° (softened at 194 °). Slightly soluble in cold water, easily soluble in hot water and cold ethanol. It can be used safely in cosmetics and has a wide range of antibacterial and antiviral activities. Can absorb ultraviolet rays. At low concentrations, it is an adjuvant that inhibits skin-type hair dyes, which is conducive to enhancing the intensity of color.

Chinese name: Coffee Acid

English name: Caffeic acid

Chemical formula: C9H8O4

Molecular weight: 180.15

Alias: 3,4-dihydroxycinnamic acid ^[2]

CAS number: 331-39-5

MDL number: MFCD00004392

EINECS number: 206-361-2

RTECS number: GD8950000

BRN number: 2210883 ^[2]

Properties: Yellow crystal (water), which turns orange when lye is irritating.

Density (g / mL, 25/4 ° C): 1.478

Melting point (ºC): 194-198

Boiling point (ºC, normal pressure): 223 ~ 225 (dec)

Flash point (ºC): 220

Solubility: soluble in hot water, ethanol, slightly soluble in cold water ^[2]

Acute toxicity

Major irritating effects:

Above the skin: Irritates the skin and mucous membranes.

Above the eyes: effects of irritation.

Sensitization: No known sensitization. ^[2]

Other harmful effects: The substance may be harmful to the environment. Special attention should be paid to water bodies. ^[2]

1. Molar refractive index: 47.47

2. Molar volume (cm ³ / mol): 121.8

3. Isometric Zhang Rong (90.2K): 362.0

4. Surface tension (dyne / cm): 77.8

5. Polarizability (10 ^-24 cm ³ ): 18.81 ^[2]

1. Hydrophobic parameter calculation reference value (XlogP): None

2.Number of hydrogen-bonded donors: 3

3.Number of hydrogen bond acceptors: 4

4.Number of rotatable chemical bonds: 2

5.Number of tautomers: 16

6. Topological molecular polar surface area 77.8

7.Number of heavy atoms: 13

8.Surface charge: 0

9.Complexity: 212

10.Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 1

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1 ^[2]

1. Stable under normal temperature and pressure.

2. Exist in tobacco leaves and smoke.

3. The alkaline solution changes from yellow to orange. ^[2]

1. Rhizomes of Cimicifuga ramifusa were extracted with methanol, and concentrated under reduced pressure to remove methanol. The residue was dissolved in heated water, and insoluble matter was filtered off while hot. After cooling, benzene was added for extraction, and the benzene solution was washed with 1% aqueous sodium hydrogen carbonate solution, and the washing solution was collected. Dilute hydrochloric acid was used to acidify, and then organic acid was freed from benzene, and concentrated under reduced pressure to remove benzene. The residue was a caffeic acid-enriched product.

2. Tobacco: FC, 53, 54. It is obtained by acid hydrolysis of chlorogenic acid. ^[2-3]

1. Intermediate of caffeic acid. For organic synthesis.

2. It can be used safely in cosmetics and has a wide range of antibacterial and antiviral activities. Can absorb ultraviolet rays. At low concentrations, it is an adjuvant that inhibits skin-type hair dyes, which is conducive to enhancing the intensity of color. ^[3]

I. Emergency Response to Leakage

Cut off the fire. Wear self-contained breathing apparatus and general fire protective clothing. Stop leaks while ensuring safety. Water spray reduces evaporation. Absorb with sand or other non-combustible adsorbent. It is then transported to an open area for burial, evaporation, or incineration. If there is a large amount of leakage, use a dike to contain it, and then collect, transfer, recycle or harmlessly dispose of it.

Second, protective measures

Respiratory protection: When the concentration in the air is high, you should wear a gas mask. It is recommended to wear a self-contained breathing apparatus for emergency or rescue.

Eye protection: Wear chemical safety protective glasses.

Body protection: Wear antistatic work clothes.

Hand protection: Wear protective gloves.

Others: Smoking is strictly prohibited on the job site. Avoid prolonged repeated exposure.

Third, first aid measures

Skin contact: Remove contaminated clothing and rinse thoroughly with soap and water.

Eye contact: Open the upper and lower eyelids immediately and rinse with running water for 15 minutes. Seek medical attention.

Inhalation: Remove from the scene to fresh air. Difficulty breathing to give oxygen. Once breathing stops, begin CPR immediately. Seek medical attention.

Ingestion: If you take it by mistake, rinse your mouth with water, drink plenty of warm water, induce vomiting, and consult a doctor immediately. ^[3]

Security identification: S26S36 / S37 / S39S36

Danger sign: R40R63R68R36 / 37/38

1. Antibacterial and antiviral: It has a broad antibacterial effect, but can be inactivated by proteins in the body. In vitro tests show that it has antiviral activity and has a strong inhibitory effect on vaccinia and adenovirus, followed by polio type I and parainfluenza type III viruses.

2. Anti-venom: At a dose of 3 micrograms of caffeic acid, it can completely inhibit 20 micrograms of rattlesnake venom phosphodiesterase, and is used as an anti-venom agent.

3. Other effects: Caffeic acid can increase the central excitability of rats when taken orally or intraperitoneally; Orally, it can increase the secretion of hydrochloric acid in the human stomach and can slow the pulse; It can increase the tension of the uterus. It is antagonized by alkali, but atropine cannot be affected; it can increase bile secretion in rats. Elevated white blood cells, hemostasis and inactivated vitamin B1. Can inhibit rat brain tissue homogenate

   Used name

   English name CAFFEIC ACID TABLETS

   Pinyin name KAFEISUAN PIAN

   Drug Category Hemostasis

   Properties This product is a light yellow tablet with a slightly acid taste.

   Pharmacology and Toxicology This product is a blood white blood cell medicine, which has the function of contracting and solidifying microvessels, improving coagulation factors, and increasing white blood cells and platelets.

   Pharmacokinetics

   Indications are used to prevent bleeding or hemostasis during surgery, and to stop bleeding in bleeding disorders such as internal medicine and obstetrics and gynecology. It is also used for leukopenia and thrombocytopenia caused by various reasons.

   Dosage Oral: 0.1 0.3g once, 3 times a day, a course of treatment on the 14th, can be applied for several consecutive courses.

   Phenethyl caffeate

   Alias: caffeic acid -phenylethanol ester

   English name: Phenethyl caffeate

   CAS number: 104594-70-9

   Molecular formula: C17H16O4

   Molecular weight: 284.31

   Packaging specifications: 25kg cardboard drum

   Specifications: 98%

   Uses: Among the many active ingredients of propolis, phenethyl caffeate has been identified as one of the main active components in propolis. Many biological activities of propolis are related to CPAE. At the same time, it also has anti-inflammatory and anti-tumor effects, and is an important raw material and intermediate for medicine. ^{[2] [4]}