What are autoimmune polyglandular syndromes?
Autoimmune polyglandular syndromes are a collection of genetic disorders that can occur in many different ways and cause a wide range of health problems. Most doctors recognize three types of autoimmune polyglandular syndromes - types I, II and III - based on specific glands and body systems that affect. The adrenal glands, thyroid, parathyroid and other glands and diabetes can be involved is a common common occurrence. Treatment depends on basic conditions, but most patients must regularly take hormonal substitute medicines and anti -inflammatory drugs to help to cope with symptoms.
Autoimmune polyglandular type I syndromes are very rare and are primarily beginning to cause problems in childhood. A child can experience several autoimmune conditions such as a combination of adrenal insufficiency, lupus, rheumatoid arthritis or parathyroid problems. Symptoms may include fatigue, vomiting, dehydration, hair loss and skin changes. Patients are also pleasant to KanDidosis, a type of recurring fungal yeast infection. Doctors have associated type syndromes with a specific genetic mutation on chromosome 21.
Autoimmune polyglandular syndromes, which are classified as type II, are more common than type I syndromes and usually do not become active until adulthood. Most people with type II syndromes suffer from the adrenal disorder called Addison's disease and a potentially serious thyroid condition called Hashimoto thyroiditis. Diabetes is also a common clinical feature of type II disorders. Patients can experience a number of symptoms such as digestive problems, memory loss, lethargy, confusion and poor muscle control. Unlike type I syndromes, type II disorders are related to more genetic mutations on more than one chromosome.
type III disorders are the least common of autoimmune polyglandular syndromes. They are Unique in that the adrenal glands are not usually affected. PlaceThis may have this person to correct thyroid disease, anemia and diabetes. Depending on the severity of hormonal imbalances and inflammatory reactions, symptoms may include malnutrition, weight fatigue, fatigue and frequent viral disease. The causes of type III disorders are not well understood, but genetic research suggests that these are more mutations.
extensive testing is needed to confirm the presence of autoimmune polyglandular syndrome and noticing any basic symptom. Doctors examine blood and urine samples to seek anemia, yeast infections and abnormal number of hormones. Imaging tests are performed to check the physical damage of the adrenal, kidneys, liver and other organs. Advanced genetic tests are also performed to determine the chromosomes involved.
Treatment is usually aimed at curing or driving any basic disorder. Patients with adrenal, bodies and thyroid problems generally need artificial hormonal therapy to balancethe attaches. Diabetes is treated with insulin injections and inflammatory conditions such as arthritis and lupus are fought with corticosteroids. There are no clear drugs for autoimmune polyglandular syndromes, but regular controls and ongoing treatment can significantly improve the symptoms and quality of life of patients.