What Are Missense Mutations?
A missense mutation refers to a base substitution mutation that can cause a change in the amino acid sequence of a polypeptide product or a change in the functional RNA base sequence. This mutation may have no effect on the expression product and may also bring benefits, but most of them bring harmful or lethal effects. (Zhang Lin) [1]
Missense mutation
- Chinese name
- Missense mutation
- Foreign name
- missense mutation
- Involve
- Amino acids, bases
- the reason
- Gene mutation
- A missense mutation refers to a base substitution mutation that can cause a change in the amino acid sequence of a polypeptide product or a change in the functional RNA base sequence. This mutation may have no effect on the expression product and may also bring benefits, but most of them bring harmful or lethal effects. (Zhang Lin) [1]
- As a result of bp substitution, the codons of one aa become the codons of another aa. When synthesizing a polypeptide, it is translated into a different aa, thereby causing gene mutation. This view is called a missense mutation.
- Missense mutation: The codon that encodes an amino acid is replaced by a codon that encodes another amino acid after base substitution, which changes the amino acid species and sequence of the polypeptide chain. The result of missense mutation can usually cause the polypeptide chain to lose its original function. Many protein abnormalities are caused by missense mutation [2] .
- Due to the replacement of bp, the codon of one aa becomes the codon of another aa. When synthesizing a polypeptide, it is translated into a different aa, thereby causing translation mutation. This mutation is called a missense mutation.
- Changes in the anti-codon region add the correct amino acid to the peptide chain to synthesize normal proteins. For example, a Glycine codon GGA in a tryptophan synthetase in an E. coli cell is mutated into AGA (encoding amino acid), which guides the synthesis of the wrong polypeptide chain. The correction gene of the glycine-corrected tRNA mutates its anti-codon from CCU to UCU. It is still the anti-codon of glycine but does not bind GGA and can be combined with the mutated AGA codon to put the correct amino acid (glycine). Put it on the corresponding position of AGA. [3]