What are Misense Mutations?

Misense mutation is a type of genetic mutation in which one base is replaced by another base that changes one "letter" in the encoding DNA sequence. Depending on where the mutation occurs and which base changes, Misense mutations may lead to health problems or can lead to no functional change. Several genetic states were associated with Misense mutations, and these mutations are also associated with a number of cancer. During the transition, purine is replaced for additional purine or pyrimidine is confused with other pyrimidine. In transversions, purine and pyrimidine are confused. Either it changes the DNA sequence, which means DNA can encode a different protein than it has in healthy individuals. Depending on where there is a mutation on the gene, this can cause different consequences when DNA encodes a different protein.

In some cases, there is no functional change or there is a change, but is minimal. In other swap it causes serious complications because the body creates a completely different protein. Some examples of genetic states caused by mutationMi Misense includes some forms of cystic fibrosis, sickle anemia and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). Misense mutations were also associated with cancer that occurs when the division of cells gets out of control. In order to confirm that Misense mutations have occurred, it is necessary to know which genes are involved in the patient's condition and identify the exact places on the gene where abnormalities occur.

Many Misense mutations is spontaneous, caused by cell division errors that caused transversion or transition. Others may be caused by exposure to mutagens such as dangerous gases. The first Misense Mutv 50 years have been identified ACE and understanding how such mutations have been working since then, due to DNA sequencing and greater genome understanding.

When the Misense mutation does not cause a functional change, it is sometimes known as a conservative or quiet mutation. People may not know the fact that in these cases they carry a mutation. Misense mutations that result inchanges are constantly identified. Medical understanding of genetic disease also moves in response to this new information, as scientists learn that the severity of genetic conditions may vary significantly, depending on changes in the genetic material of the individual patient.