What Are Senile Plaques?
A skin degenerative change for the elderly. Appeared as scattered pigment patches, ranging in size, flat or slightly higher than the skin, the surface is smooth, brown. More common in exposed areas, such as the face, forehead, back of the hand and so on.
- Chinese name
- Age spots
- Foreign name
- senile plaque, SP
- A skin degenerative change for the elderly. Appeared as scattered pigment patches, ranging in size, flat or slightly higher than the skin, the surface is smooth, brown. More common in exposed areas, such as the face, forehead, back of the hand and so on.
Causes of senile plaques and common diseases
- Senile plaques are mainly -amyloid, which is polymerized from amyloid precursor hydrolyzed fragments.
Senile plaque differential diagnosis
- There are two types of SP: typical (mature) and atypical (immature). Typical SPs account for only a small number of SPs in AD brains. The core of the SPs contains many amyloid filaments with a diameter of about 8 nm. Nerve processes are surrounded by astrocytes and activated microglia to form dense fibrous plaques, usually spherical, with a diameter of 10 to several hundred microns. Atypical SP is also called diffuse amyloid plaque. Most of them are amorphous, low-density amyloid deposits, and there are no dystrophic neurites and glial cells.
- Some data show that atypical SP can gradually become typical SP, but the specific process is still unclear. SP is mainly located outside the blood vessels, but some scholars have also found SP in the vascular basement membrane. It is mainly composed of two types of substances, one is a disease-specific protein. All SPs contain a characteristic B-amyloid protein (AB ). The other is disease-related proteins such as O1-antichymotrypsin, apolipoprotein-E, collagen V, complement factor, aminoglucan (GAG), Ig, laminin, proteoglycan, and thrombospondin Wait.
Senile Plaque Examination
- SP is a broken nerve fiber network under the electron microscope, which is spherical and distributed in the neocortex, hippocampus and amygdala.
Senile plaque treatment principles
- The traditional methods include CO2 laser, ion cauterization, freezing, grinding, and surgical skin grafting. These methods are prone to adverse reactions such as scarring and pigmentation.