What are the causes of anemia of sickle cells?
The primary causes of anemia of sickle cells (SCA), also known as SCD, are largely caused by genetic mutation in the hemoglobin of the body, specifically in chromosome 11. Children of two SCA individuals are generally born with this disease, while children with one of the parents suffering from SCA usually do not experience any remarkable symptoms. The causes of anemia of sickle cells are also related to blood problems such as dehydration, low oxygen levels and increased acidity.
The causes of anemia of sickle cells can be attributed to a mutation in hemoglobin, a compound rich in iron, which gives blood its red color. Normally, red blood cells are in the form of disk and full due to the presence of glutamic acid. The mutation that causes the Sca occurs in the beta-globin gene, which in turn causes the replacement of glutamic acid with valine. Chemical change causes red clippings have become stiff, sticky and definedOrdered, similar to the shape to a crescent month.
The genetic causes of anemia of sickle cells are transmitted to the next generation by a model called autosomal recessive inheritance. This means that both parents should go through the gene to inherit this disease. If only one parent bears the mutation, the child will have what scientists call the "characteristics of sickle cells".
individuals with the properties of sickle cells have both normal and mutated hemoglobin and could potentially pass the Sca to their children. However, the sickle cell brand shows no symptoms outside a series of sickle -like blood cells and is considered harmless to the patient. With each pregnancy they have two parents who have the characteristics of a sickle cell without a blood cell mutation.
The causes of anemia of sickle cells are also associated with certain physical conditions. Red blood cell distortion in individuals with mutation is generally caused by a low blood volume. Among othersThe contributing factors include dehydration, low blood oxygen levels and increased blood acid. It is also assumed that cardiac August in individuals with the properties of sickle cells is associated with high metabolic activity. Pregnant women are considered more susceptible to cellular August due to increased uterine activity and hormonal imbalances.