What is activated resistance to protein C?
Activated resistance to protein C concerns blood or hematic disorder that occurs when the enzyme fails to regulate blood clotting, resulting in abnormal venous thrombosis. More than 80 percent of the time is inherited. Once treatment is diagnosed, heparin injections include lifelong oral warfarin therapy.
Protein C is normally activated when exposed to thrombin combined with thrombomodulin on endothelial cells or blood vessel lining. After activation of protein C, it usually breaks down the clotting of VA and VIIIA factors, which prevents the formation of a blood clot. Scientists have found that the inherited disorder includes mutation in the coating of factor V. This mutation, called the Leiden factor, makes this particular immune or resistant to the effects of activated protein C, which negotiates an anticoagulant response.
Scientists suggest that the risk of thrombosis is nearly eight times greater activated resistance to protein C, which is inherited, ine Comparison with an average person. The risk generally increases dramatically to 90 times higher in those who inherit the identical pairs of the gene. Deep venous thrombosis (DVT) is a common symptom, but blood clots can form anywhere along the venous system. Abnormal production of blood clots may occur as early as adolescents and biological stressors, which include infection, pregnancy or surgery, usually contribute factors.
Cancer, inflammatory diseases and lupus can bring the activated resistance to protein C. The disorder can also cause high cholesterol, oral contraceptive use and pregnancy. There is no mutation of factor clotting in the obtained failure. In the case of lupus, chemical reactions in the body cause factor resistance in without mutation. In other conditions, scientists believe that activated PK resistance to Rotein C is running out because the body is experiencing abnormally high levels of precipitationThe factors VII and VIII and perhaps higher levels of fibrinogen. Without a sufficient amount of activated protein C, these increased clotting of factors cause blood clots.
When doctors suspect activated protein C, they can perform prothrombin time (PT) and activate partial thromboplastin times (APTT). PT and APTT include the time it takes to normally precipitate and after adding calcium and phospholipid. In the absence of possible infections or autoimmune diseases, activated resistance to protein C could be added to the plasma to evaluate the clotting time with the substance as opposed to normal PT times. Similar times between the two tests may indicate a failure. Further testing may include identifying factor mutation in Leiden.