What Is Autoimmunity?
Autoimmunity is that under normal circumstances, the animal's immune system only reacts to foreign body antigens other than itself, but for some reason causes an immune response to its constituents, it is called autoimmunity.
- Chinese name
- self-immune
- Foreign name
- Autoimmune
- Scope of application
- Health psychology
- Definition
- Self acquired immunity
- Autoimmunity is that under normal circumstances, the animal's immune system only reacts to foreign body antigens other than itself, but for some reason causes an immune response to its constituents, it is called autoimmunity.
Autoimmune definition
- Refers to the phenomenon that the body's immune system responds to its own antigen, producing low levels of antibodies and sensitizing lymphocytes.
Autoimmune classification
- Autoimmunity can occur in the following two situations: (1) Like antigens of the brain parenchyma, eyeballs, and sperm, antigens that are usually isolated from the immune system, leak out of tissue due to tissue inflammation and other reasons, or due to lymphocyte Infiltrate into tissue and cause immune response. Therefore, although the immune response in this case is autoimmune to the individual, it is the same as the immune response to the foreign body antigen in terms of the immune system. (2) Although the lymphoid cells (immune-active cells) involved in immunity often come into contact with their own components, the latter are not the object of the response (immunotolerance). However, when the tolerance of the immune-active cell population fails for some reason, autoimmunity is caused.
Autoimmune physiological phenomenon
- There are a certain amount of autoreactive T cells in the body of healthy individuals, and they play a role in maintaining the homeostasis of the immune system. For example, anti-idiotypic antibodies, anti-nuclear antibodies, anti-mitochondrial antibodies, rheumatoid factor (RF) and other autoantibodies can be detected in normal human serum. Certain autoantibodies may have important physiological functions. For example: anti-idiotypic antibodies have immunomodulatory effects, and RF is an antibody against denatured IgG, which can bind to multivalent IgG, thereby helping to clear the immune complexes in the circulation through monocyte-phagocytic cells. Most autoantibodies have low titers, which are not enough to cause damage to their own tissues, but they can help to clear their own components of aging and transformation, so they are also called "physiological autoantibodies"