What Is Bisulfite Sequencing?

RRBS (Reduced representation bisulfite sequencing) is a degenerate representative bisulfite sequencing technology. Is an efficient high-throughput sequencing technology for single-nucleotide-level methylation level analysis of the genome. This technology combines restriction enzymes and bisulfite sequencing to obtain enrichment information for high CpG regions. Compared with genome-wide methylation sequencing technology, RRBS only needs to sequence about 1% of the genome ^[1] , so the cost is greatly reduced.