What Is Cyclooxygenase?

Oxygenase (COX) is a rate-limiting enzyme for arachidonic acid metabolism. It has dual functions of cyclooxygenase and peroxidase.

Oxygenase

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Oxygenase (COX) is a rate-limiting enzyme for arachidonic acid metabolism. It has dual functions of cyclooxygenase and peroxidase.

Oxygenase is divided into cyclooxygenase and heme oxygenase.

At present, there are two subtypes of COX, namely COX-1 and COX-2. Among them, COX-2 is an inducible enzyme with enhanced expression in the case of tissue damage and inflammation. Recent studies have found that COX-2 is closely related to tumorigenesis and development, tumor neovascularization, and tumor metastasis, and COX-2 inhibitors are expected to become new targets for tumor treatment. This article reviews the recent advances in research on the expression, regulation and carcinogenesis of COX-2 in endometrial cancer at home and abroad, and provides new targets for the prevention and treatment of endometrial cancer.

To study the expression of heme oxygenase.1 (HO.1) / carbon monoxide (CO) system in rats with pulmonary fibrosis and the effect of drug intervention to provide a new method for the diagnosis and treatment of pulmonary fibrosis.

Sixty Wistar rats were randomly divided into four groups: control group, pulmonary fibrosis group (fibrosis group), pulmonary fibrosis plus HO. 1 specific agonist group (enhancing group), lung vitaliation plus HO .1 specific inhibitor group (inhibition group). The expression of HO.1 / CO system in lung tissue and serum of rats in each model group was detected, the role of HO.1 / CO system in pulmonary fibrosis in rats, and the effect of drugs on the degree of pulmonary fibrosis were analyzed. Results In the control group, HO.1 and COHb were under-expressed in rat lung tissue and serum, and there was no significant difference between the two (P> 0.05). In comparison, HO.1 and COHb were highly expressed in rat lung tissue and serum, with the enhancement group as the focus and the inhibition group as the lowest. The difference between the two was statistically significant (P <0.05). Conclusion The HO.1 / CO system is involved in the formation of pulmonary fibrosis in rats. The intervention can change the degree of pulmonary fibrosis in rats and provide a new way for the diagnosis and treatment of pulmonary fibrosis.