What is the lack of glutathion?

Glutathion deficiency, also known as glutathion synthetase, is a disorder that prevents the body to produce glutathion, a molecule that consists of three amino acids and is necessary while maintaining the normal function of the body's immune system. Glutathion prevents cell damage by destruction of harmful or unstable molecules produced during the energy process. It also helps in the construction of deoxyribonucleic acid (DNA) and protein and plays a key role in the processing of drugs and carcinogens that could enter the body. Lack caused mainly by mutation or a number of mutations in the glutathion synthetase gene. The condition may be inheritance, but metabolic disorders such as diabetes and various congenital conditions can also cause deficiency.

Glutathion deficiency occurs in three phases: moderate, medium and serious. Some initial symptoms of glutathionic deficiency - vomiting, diarrhea, anemia and abdominal pain - are the same as thadica of other diseases as multiple sclerosis oro Lack of vitamin B12. When there is a lack of glutathione, blood, urine and spinal cord, a compound called 5-oxoprolin accumulates. This condition is called 5-oxprolinuria. Other symptoms include haemolytic anemia caused by the destruction of red blood cells and metabolic acidosis resulting from the accumulation of lactic acid in blood, urine and spinal cord. The slight symptoms of glutathion deficiency are the same mild symptoms, but are considered more serious because they occur shortly after birth.

The severe symptoms of glutathion deficiency are neurological disorders such as psychomotor retardation, which is characterized by a generalized delay of physical reaction, movement and speech. There may also be seizures, loss of coordination and intellectual damage. Another less common symptom is recurring bacterial infections in some cases.

Glutathion deficiency is treated primarily by dosing withMoon of sodium and citric acid to correct metabolic acidosis and antioxidant vitamins E and C. This could be enough to restore glutathion levels, depending on how soon the deficiency is diagnosed. Alfa-lipoic acid and n-acetylcysteine ​​(NAC) were also used in the treatment of deficiency. Alfa-lipoic acid is an antioxidant considered to be more effective than vitamins E and C. It is believed that NAC increases low levels of glutathion and cysteine ​​in leukocytes in patients.

Although it is a rare disorder, the lack of glutathion is a chronic, life -threatening condition. After treatment, regular, periodic monitoring with a metabolic specialist is usually necessary. Patients with a mild or mild case may usually live with the condition under the supervision of a doctor. The prognosis for patients with severe deficiency is less optimistic. Even with treatment, patients can still be left seriously retarded and/or experience seizures and neurological deterioration.