What is hyperalgesia?

hyperalgesia is a phenomenon that creates an increased response of the nervous system to any stimulus. This reaction is so intense that the human brain interprets these signals as intense pain. It can be experienced in focal areas or in a more general way throughout the body. There are a number of conditional studies that have shown that it is possible to suffer from learned hyperalgesia.

There are two types of focal hyperalgesia, which are usually the result of a type of physical injury. Primary hyperalgesia exists when sensitivity to pain occurs directly in damaged tissues, while a secondary form is sensitivity to the pain that occurs in peripheral nerves that have not been damaged during the injury. Normally, this is because there has been some damage to the surrounding sensory receptors or nociceptors. There is also hyperalgesia induced opioids that can develop as long -term use of opioids. This usually occurs because chronic pain is used opioids.

specific mechanisms that cause hyperalgesia are different and in some cases they are misunderstood. This is most often due to a factor of the activating plate (paf), which is a normal reaction of the body to allergies or muscle inflammation. Immune cells essentially interact with the peripheral nervous system and release cytokines and chemokins, which are pain producing hormones. Hyperalgesia may also be caused by fibers of the body in the body that are stimulated in the same pattern as inflammation. This creates reinforcement of synapses of pain fibers through the nerves in the spinal cord.

people who have been exposed to opioids such as oxycodone or heroin for a longer period of time are endangered by hyperalgesia of induced opioids. Opioids are commonly used to treat chronic pain, and when a person reports a higher level of pain than suggests physical findings, the dosage will often have the dosage to be treated for hyperalgesia, was crumpled.Constant hyper-stimulation of opioid receptors will then change the level of homeostasis in pain signaling.

hyperalgesia shows similarity to other types of pain disorders that are better understood, such as alodynia. This condition in all its forms is not fully understood and does not have its own standardized treatment, so most people will be treated as an alodynia. This means that they have the opportunity to use different drugs, including tricyclic antidepressants, pregabalin, tramadol and more. From a clinical point of view, the creation of a therapeutic regiment is very difficult because it relies on testing a series of drug combinations until one is working. In the case of hyperalgesia of induced opioids, there is a chance that simply reduced opioid dosage levels can lead to improvement.