What is a paraneoplastic pemfigus?

Paraneoplastic pemphigus (PNP) is an autoimmune disease that adversely affects the skin and mucosal membranes. Symptoms usually include blisters in the oral cavity and esophagus, as well as in the genital area and sometimes in the lungs. Fever, chills and other symptoms similar to flu can be represented. Individuals with certain types of cancer, such as lymphoma, are often diagnosed with this chronic condition. There is no medicine for paraneoplastic pemfigus, so treatment is generally focused on the treatment of symptoms and is entirely dependent on the severity of the presentation of symptoms.

There is no known, definitive cause of the development of paraneoplastic pemfig. In the presence of an autoimmune state, the immune system is not able to distinguish between foreign and known substances, which causes the development of unnecessary antibodies. The immune response of someone with a paraneoplastic pemfigu involves the production of proposed antibody a proteins known as desmogleins that play a key role in the stabilization of the leatherthe cells. In antibodies attack, skin cells are separated from each other, resulting in blistering.

Pemphigus diagnosis generally results from the elimination process. Given the ubiquity of blisters as a symptom, the symptoms of Pemphig may be confused with those associated with a different condition. Given the development of blisters induced by Pemphig, it is usually limited to the oral cavity and the genital area, a number of diagnostic tests may be administered to confirm the diagnosis. Symptomatic individuals generally undergo a blood test and a skin biopsy to verify the presence of antibodies associated with Pemphigus known as anti-decmogleins.

individuals with paraneoplastic pemfigu generally develop blisters inside and without the oral cavity and esophagus. It is also not uncommon for some individuals to develop blisters in the lungs that may threatenIT their ability to breathe. Other symptoms of Pemphigus may include symptoms of fever and flu such as widespread pain and chills.

If it is not treated, the paraneoplastic symptoms of Pemphig may proceed, leading to the spread of blisters to other dermal areas, including face and chest. Blisters that burst and infected can contribute to the development of blood infection known as sepsis, if appropriate treatment is delayed or absent. Since individuals with malignant state often have endangered immunity, they may be more susceptible to infection. Further complications of paraneoplastic pemfigus may include serious damage to breathing and premature death.

timely and appropriate treatment is essential for the management of someone's symptoms and slowing down the disease progression. Mild presentations generally require corticosteroid drugs to facilitate inflammation. In some cases, antibiotic and antiviral drugs can be used to eliminate infection and prevent reinfection. Heavy Presentation ParaneoplAstical Pemfig often requires a more complicated treatment approach.

with severe or extensive infection may require hospitalization to stabilize their condition. When the importance and severity of blisters in the oral cavity prevents food or drink, intravenous fluids and nutrients are administered, including electrolytes and potassium to facilitate nutritional balance and prevent dehydration. In some cases, the process known as therapeutic plasmapheresis to clean the plasma of the individual of unnecessary antibodies that contribute to the constant deterioration of symptoms and accelerated disease progression.