What is Pemphigoid?

Pemphigoid is a term used to indicate a group of skin conditions, which are mainly manifested by blistering. Although in the presentation such as Pemphigus, these blisters occur without acantolysis or the destruction of intercellular connections and cohesion of adjacent keratinocytes of the skin. This condition tends to occur more often in women and elderly. As such, they can be classified according to what is immunoglobulin. Pemfigoid gestationis (PG), bullous pemfigoid (BP) and mucous membranes or ceatricial pemfigoid (MMP/CP) include immunoglobulin G (IgG). Another classification called immunoglobulin and (IgA) pemphigoid includes IgA.

, as the name suggests, PG or herpes gestationis, is associated with pregnancy, usually appear in the second or third trimester or immediately after delivery. MMP/CP and BP generally affect people aged 60 years and over. While MMP/CP does not include the skin, BP rarely affects the mouth.

In BP, the skin involve the inner surfaces of the thighs, aspects of forearm flexors, weaknesses, armpits and lower legs and can be associated with lesions similar to hive and extreme itching or itching. Some people with this condition may have oral blisters that appear on the skin blisters. Lees are tense blisters or bulle, full of clear fluids and found on normal or reddish skin. These blisters generally have an average diameter of 0.8 inches (2 cm), but can occasionally reach 1.6 to 3.1 inches (4 to 8 cm).

BP blisters achieve only subepidermis and not dermis, so they are not prone to burst or scarring. However, the bucket of bullae leads. As a result, the skin is susceptible to secondary bacterial infection that could achieve a dermis, leading to scarring.

Pemphigoid is often a diagnosis of exclusion, administered after inflammatory and infectious causes of acute or chronic blisters. Diagnosis includes proper examination of skin lesions, skin biopsy and immunohistologicala method called direct immunofluorescence. After microscopic examination of the biopsied skin, pemphigoid would show a vacuulous basal cell layer, which extends only subepidermally, without acantolysis. Desmoglein antibodies would test positive for direct immunofluorescence of a biopsy sample. To detect desmoglein antibodies present in the blood, an immunosorbent test (ELISA) test was developed to detect desmoglein antibodies.

Treatment of this chronic blister disease involves administration of topical or oral corticosteroids to reduce antibodies. Examples include prednisolone and prednisone. Obrazi treatment options include dapsone, erythromycin, cyclosporin, cyclophosphamide, azathioprine and mycophenolate Mofetil.