What is the primary ciliary dyskinesia?
primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by abnormal movement of cilia in the human body. Cilia are small, whip structures that line the respiratory system including lungs, esophagus, neck, nasal passages and ears. When the cilia works properly, they defeated in accordance and helped to proceed through the mucous membrane through the respiratory system into the throat, so it can be excluded by cough. If the cilia does not move or move incorrectly, the mucous membranes cannot move the body properly and the possibility of infection increases dramatically. One condition that was eventually included under the diagnosis of PCD is Kartagner's syndrome. The Swiss doctor Manes Kartgener identified a cluster of symptoms in 1933, which included chronic bronchitis and sinus infections, as well as situs inversus , or the conversion of organs in the human body. People with Cartager syndrome were later found to have abnormal cilia and this syndrome was subsequently included under the diagnosis of primary ciliary dyskinesia.
common health problems associated with PCD include chronic bronchial and sinus infections, difficult to cleanse mucous membranes, tendency to ear infections and infertility. It is not unusual that people with PCD suffer from hearing loss due to chronic ear infections. The problem is also infertility, although in vitro fertilization can be used as an alternative form of conception. The disease is not generally fatal, but recurring respiratory infections take a tax on the body and can lead to permanent damage.
Due to increased problems with respiration, people with primary ciliary dyskinesia often require antibiotics to treat infections. Higher doses of frequent antibiotic courses can lead to greater susceptibility to tribes of bacteria resistant to drugs. Antibiotics can also kill or inhibit friendly bacteria in the body, resulting in fungal infection. Other common treatments for people with PCDs include mucous membranes and various forms of chest therapy. In the caseH, where this less invasive treatment proves inefficient, surgery can be used.
primary ciliary dyskinesia is often incorrectly diagnosed, partly due to secondary diseases are so common and relatively small. Another reason for frequent incorrect diagnosis is that the PCD is so rare. Most doctors begin to diagnose by examining more common diseases such as asthma or allergy. Accurate diagnosis generally requires bronchial or nasal tissue biopsy, a more invasive procedure. The high incidence of incorrect diagnosis is unfortunate because early diagnosis can help reduce long -term damage, especially for the respiratory system, ie caused chronic infections associated with PCDs.