What Is the Connection Between Creatine and Kidney Damage?

Phosphocreatine is a high-energy phosphate compound in muscle or other excitable tissues such as the brain and nerves. It is a temporary storage form of high-energy phosphate groups. When creatine phosphate is hydrolyzed, it releases 10.3 kcal of free energy per mole of compound, which is more than the energy released by ATP (7.3 kcal per mole). Phosphocreatine can transfer its phosphate group to ADP molecule under the catalysis of creatine kinase. When some ATP is used for muscle contraction, ADP is produced. At this time, through the action of creatine kinase, creatine phosphate quickly supplies ADP with phosphate groups, thereby restoring normal high levels of ATP. Since the content of creatine phosphate in muscle cells is 3 to 4 times its ATP content, the former can store sufficient phosphate groups for short-term activities. During the recovery period after the activity, the accumulated creatine can be phosphorylated by ATP and regenerate creatine phosphate, which is a reverse reaction catalyzed by the same enzyme. Because there are no other metabolic pathways in the cell that synthesize and break down creatine phosphate, this compound is well suited to perform this temporary storage function. In many invertebrates, phosphoarginine replaces phosphocreatine as a capable storage form. The human sprint can be used as an example to illustrate the function of creatine phosphate. The content of creatine phosphate in muscle is 17 micromoles / g. A full-speed sprint can consume 13 micromoles of creatine phosphate, so it can only be used as an energy source for the first 4 seconds, but it can provide time to regulate glycolysis. Enzyme activity enables muscles to obtain energy through fermentation.

Basic properties

Chinese name:

CAS number: 67-07-2

MDL: No

EINECS number: 200-643-9

RTECS number: No

BRN: No

PubChem number: ^[1]

No

No

1. Molar refractive index: 40.83

2. Molar volume (cm3 / mol): 115.2

3. Isotonic specific volume (90.2K): 362.9

4. Surface tension (dyne / cm): 98.3

5. Polarizability (10-24cm3): 16.18 ^[1]

Pharmacological action

The main active ingredient of creatine phosphate is creatine phosphate, which acts as a supplement

Phosphocreatine is a cardioprotective agent. It is clinically used to treat insufficient striated muscle activity, and is used as an adjuvant therapy for heart disease, but it cannot replace the dynamic therapy of the heart. Can also be added to the cardiac arrest solution, as one of the protective measures for cardiac surgery. Foreign data can also be used as nutritional supplement drugs to treat metabolic diseases.