What is the history of anemia of sickle cells?

Although it is likely that anemia of sickle cells, a genetic state that causes the abnormality of red blood cells, has existed for millennia, the history of scientific knowledge has begun relatively recently. In this sense, the history of the anemia of the sickle cells began in 1910, when the situation was first identified by medical scientists. Over the next decade, scientists have expanded their understanding of the condition and discovered, for example, its relationship to oxygen, genetics and hemoglobin. At the beginning of the 21st century, the history of anemia of sickle cells continues to be written when medical experts are looking for treatment and even drugs. The abnormal structure of hemoglobin in persons with condition causes normally round red blood cells to occupy the shape of a crescent. In return, these wrong cells can cause a number of problems. They can be stored in blood vessels, causing mild to severe pain, and also tend to disintegrate much faster than normal red blood cells, leading to blood that has a low oxygen content. Anemia to the shitThese cells are genetic and are only manifested in those who have inherited the property of the sickle cells from both their parents.

Indian, Middle East and Mediterranean may suffer from anemia of sickle cells, but most often affects people of African origin. In fact, it has many African tribal languages ​​for the condition of the word, suggesting that there are many generations. However, its causes would remain unknown until the beginning of the 20th century.

The medical history of the anemia of the sickle cells began in 1910, when an American doctor named James Herrick used a microscope to study the Caribbean Man's blood cells who experienced body and lethargy. Dr. Herrick found that male red blood cells showed an unusual shape. When he published his findings, he described the cells as "sickle -shaped shapes", giving the condition the name.

in the decades that followed the discovery of Dr. Herrick, scientists began to combine the pathology of the disease. MedicineThe Ara determined that the condition caused low blood oxygen in 1927, while two separate scientists published a work that showed that it was hereditary in 1949. Two scientists, Dr. Linus Pauling and Dr. Harvey Itano, founded in 1951, founded in 1951 is responsible for the shape of the hair of red blood cells.

Since the mid -20th century, the history of anemia of sickle cells to a large extent includes the search for effective treatments and the treatment of the condition. In the age of 80, it was found that the drug could be carried out with bone marrow transplantation, which replaces abnormal cells of normal Red blood cells. Since this procedure is extremely invasive and may not be successful, but scientists continue to seek satisfactory treatment. In 1995, scientists found that a drug called Hydroxyurea could significantly minimize pain often associated with this disease.