What is Wermer's syndrome?
Wermer syndrome, also known as more endocrine neoplasia of type 1 or Men1, is a relatively rare genetic disorder that usually causes more tumors of the endocrine gland, as well as tumors in the duodenum and stomach. For the pituitary gland, abdominal and parathyroid glands of people with Wermer syndrome, more tumors are generally formed. These tumors can increase the production of endocrine hormones, leading to hormonal imbalances and a number of health effects. Men1 is considered hereditary and children, parents or siblings who have it believe that they had a 50% chance themselves. Symptoms of Wermer syndrome, which may vary considerably in case of case, usually do not appear until adulthood and can usually be well managed to prevent complications. Parents, siblings and children of the person diagnosed with the disease are usually also cheered on the gene mutation that causes it. Men and women can develop this disease and symptoms may occur at any age, even if they usually have an objectthey evil in adulthood. These diseases appear to be the same in all races and geographical regions. Approximately one in 30,000 people develops this disease, so it is considered rare.
Multiple endorcine type 1 neoplasia generally causes multiple tumors in the endocrine glands of the body. These glands include the pancreas, trunk and pituitary. Tumors in the endocrine glands may cause these glands to become excessively active, leading to a wide range of health problems due to hormonal imbalances.
tumors in the next body glands can cause hyperparathryoidism, a condition that causes parathoroid glands to form excessive amounts of their hormone. High levels of bodin hormones in the body can increase calcium levels in the blood weakening of bones, kidney stones and renal tissue damage. Other symptoms may include fatigue, weakness, pain in Sramparts or bones, digestive problems and constipation.
pancreatic complications may occur as a result of tumors in the pancreas and duodenum. Tumors in this area may increase insulin and glucagon levels, hormones that help regulate blood sugar. Increased insulin levels can lead to diabetes, while elevated glucagon levels can cause hypoglycemia or dangerously low blood sugar. Stomach tumors can also develop, leading to severe stomach lining and diarrhea. Hypophysis tumors in people with Wermer syndrome can cause excessive bone growth and reproductive problems.
treatment of Wermer syndrome tumors generally includes surgery. Tumors and in some cases the glands themselves may be removed. Radiation therapy is sometimes given to stop the growth of tumors or reduce their size.