What are monoamine oxidase inhibitors?

Monoamine oxidase inhibitors are the older class of antidepressants, also known as Maoi s. They are most commonly used to treat atypical depression and to cease smoking. This class of antidepressants is used less often than other classes due to serious diet restrictions. There may be fatal interactions with other medicines, supplements and types of food or alcohol. Examples of neurotransmitters involved in mood are serotonin and noradrenaline. If there are not enough of these compounds in the body, depression may occur. These specific compounds are monoamins , which means that they have a group of NH _{2 . Monoamins are degraded by an enzyme called monoamine oxidase .}

Monoamine oxidase inhibitor acts by preventing monoamine inhibit monoamine inhibit monoamine oxidase. This allows you to accumulate neurotransmitters involved in moods to reverse depression. Inhibitors of monoamine oxidases were introduced in the 1950s of the 20th century, but for a moment they were withdrawn from the market for FAtal interactions with other substances.

Some meals contain monoamins such as amino acid tryptophan or its product of decomposition, tyramine . It is important to avoid foods containing these substances - and certain drugs - when using monoamine oxidase inhibitors, but this was not known when these drugs were first introduced. One should avoid most alcoholic beverages, old cheeses, pickles, Fava or wide beans and liver. People using these drugs should also minimize the amount of chocolate consumed. A large list of food should be avoided when this type of drug is prevented, for example, tyramine interacts with a monoamiinhibitor not oxidase causes a large increase in blood pressure and can cause stroke.

One must also be careful with medicines and food supplements such as St. Johns wort because interactions can be fatal. It is also necessary to avoidUT illegal and legal stimulants, including cold patterns that contain pseudofedrin . Painkillers Demerol®, Dextromorfan - a common component in cough syrup - and asthma inhalers, along with many other drugs, are also dangerous when taking this type of drug. It may be fatal to receive antidepressant class Selective inhibitors of reoculating-noamine oxidase at the same time as inhibitors of monoamine oxidase. Before switching between these antidepressant classes, two weeks and five weeks in the case of ProVAC® should be allowed.

Due to these preventive measures, monoamine oxidase inhibitors are generally the last choice of antidepressants to treat depression. However, they can, but for some patients, especially for patients with atypical depression and social phobia, are a good choice. With atypical depression, patients often have mixed depression and anxiety. Another group of people who often help these drugs are those who suffer from panic attacks or agorafobia .However, this antidepressant class is generally not used in cases of severe depression.

For monoamine oxidase inhibitors there is an advantage because they do not cause insensitive people to become suicidal. This may be a side effect of some other classes of antidepressants. However, they are a bad choice for potentially suicidal patients, as they could be toxic at high doses and could be used as an overdose method. Many people carry an identification card that warns emergency personnel that they use monoamine oxidase inhibitor. These types of drugs should not be used by pregnant women or children under 16 years of age.

usually pre -regimezi monoamine oxidase inhibitors belong to phenelzin, which is also known as Nardil®; Tranylcypromin, sold as Parnate®; and isocarboxazid, which is also called Marplan®. There is another medicine that is worn as a skin patch that has fewer side effects at low doses. It is a delegilin, also known as EMSAM®. When using this drugand a measure must still be taken.

There is a newer class of monoamine oxidase inhibitors known as rim for reversible inhibitors of monoamine oxidases A . This Maois class is reversible and does not interact with tyramine so strongly, so food interaction is less problem. One should still not eat excessive amounts of food containing tyramine and avoid drugs that cause side effects in older monoamine inhibitors. These types of drugs are used to treat large depression.