What are the most common interactions of clopidogrel?
Clopidogrel is generally received by drugs against dealets, people who have suffered a heart attack, stroke or other clotting, and people who have a high risk of clots. Medicines effectively reduce the body's ability to create clots partially inhibit the function of the pads. The enzyme metabolizes the drug into its active form after ingestion. In cases where this enzyme is defective, the personalized dosing of the clopidogrel is necessary to prevent side effects. The use of certain drugs that are also metabolised by this enzyme can lead to several common interactions with clopidogrel, including the increased risk of blood clots and the risk of bleeding from the gastrointestinal tract. People who have previously collided but are at high risk of clots can also use the drug. To achieve inhibition of the pad function, the therapeutic effect of the drug is the effect, clopidogrel must first be metabolized into its active form in the body. This process is directly associated with the function of CYP2C19, the enzyme that is responsible for the metabolism of several drugs. Subnormal or poor enzymatic activity CYP2C19 is not unusual and may lead to increased risk of side effects and drug interactions.
people who have serious or mild defects in the metabolic activity of the CYP219 enzyme should be aware that the simultaneous use of clopidogrel with other drugs metabolized by this enzyme can lead to serious interactions of clopidogrel. Proton pump inhibitors such as lansoprazole are a class of drugs that are usually used by people who have a heavy sour reflux, gastritis or stomach ulcers. The most common clopidogrel interactions are seen in patients who use any type of drug inhibitors of proton pump together foldidogrel. Inhibitors of proton pump inhibitors within 12 hours of receiving clopidogrel significantly reduce the inhibition of plates. This increases the risk of clot formation.
Concomitant use of clopidogrel and non -steroidal anti -inflammatory drugs can also leadFor interactions of clopidogrel in the form of an increased risk of bleeding from the gastrointestinal tract. The possibility of drug interactions fails, even if the drugs are several hours apart. People who are treated with clopidogrel should not use aspirin or other drug drugs without consulting a health care expert, as the cumulative effect of drugs could significantly increase the potential for bleeding episodes due to the interaction of clopidogrel.
Scientific studies suggest that there is a possibility for interaction of clopidogrel with selective serotonin reuptake inhibitors (SSRI), class of antidepressant drugs. Concurrent use of SSRI with clopidogrel is grimly associated with a small increase in the risk of bleeding. This is generally considered to be one of the most common clopidogrel interactions.