What are the advantages and disadvantages of using stem cell transplantation for multiple myeloma?
stem cell transplantation for multiple myeloma may prolong life in some patients. On the other hand, the procedure of rescue can have serious complications, including secondary cancer, graft failure and even death. Slight reactions include bleeding and infections, while less serious complications such as infertility and cataract may also occur. After a successful support of the procedure, some patients often experience remission of symptoms and disease progression. Patients with multiple myeloma can choose between autologous and allogenic stem cell transplantation. Autologous stem cell transplantation includes the harvest of the patient's own stem cells, while the allogeneic stem cell transplantation harvesters stem cells from a tight corresponding donor.
The process of stem cell transplantation brings the possibility of prolonged life, but graduates brings a serious risk. Finally, each patient will have different reactions from small to very serious side effects. It is known that the infertility and cataract forIt is dressed in patients with multiple myeloma after complete radiation of the body that occurs before the treatment of stem cells. In case of infertility, hormone substitution therapy will be necessary for ovulation. Those who receive steroids in conjunction with stem cell transplantation have a better chance of developing cataracts.
abnormal bleeding or thrombocytopenia and infections are potentially serious complications of stem cell transplantation for multiple myeloma. Thrombocytopenia is a low number of platelets in the blood. The condition may result in excessive bleeding and bruising. Optionunistic infections also pose a mild to serious risk for the well -being and recovery of the patient, especially if they are immunosuppressive drugs. Bacterial infections are treated with strong antibiotics, while fungal infections are treated with antifungals such as fluconazole.
Much more serious consequences of accepting stem cell transplantationIt eats secondary cancer such as leukemia and lymphoma, especially those that occur in some patients with more myeloma who received chemotherapy and radiation before stem cell transplantation. Stepper failure and Štěpu-Versus host (GVHD) are two life-threatening complications that can lead to organs failure and even death. In the case of graft failure, stem cells fail to grow, resulting in bone marrow failure. GVHD includes transplanted donor stem cells to attack the recipient's body. The recipients of allogenic transplantation are at greater risk of developing acute and chronic forms of GVHD than those who receive autologous stem cell transplantation for multiple myeloma.