What factors affect the sufficient dose of fentanyl?
Fentanyl is a narcotic used as an analgesic or remedy for relieving pain, which is about 100 times as strong as morphine. It is also used as in anesthesia and as a sedative for children. The appropriate dose of fentanyl varies considerably depending on the intended application and the administration method; It is important to use a lower fentanyl dose for patients who are young, older, weakened or suffer from reduced kidney or liver function. Medicines can be administered by injection, cosmetic, sublingual tablet or transdermal patch. As a result of the cross tolerance of opioids, patients who use other narcotic drugs will be a higher initial dose of fentanyl.
When used as a supplement to anesthesia, fentanyl citrate is generally administered by intramuscular injection. Doses between 50 and 100 mcg should be used as premedications. If there are lozenges instead of injection, 5 MCG per kilogram of patient's weight is standard and should not exceed 400 MCG. When the medicine as a supplement to regional anesthesia is a dose of the sameNaz as an intramuscular injection anesthesia, although it can also be administered as an intravenous drip for three to five minutes. Postoperative doses of pain treatment can also be injected intramuscularly at 50 to 100 mcg doses.
Dosage considerations for the use of fentanyl under general anesthesia are more complex and differ considerably according to the severity and duration of the procedure. Minor operations require 2 mcg per kilogram of body weight, while the dose for normal operations is 2 to 20 mcg per kilogram and maintenance doses of 25 to 100 mcg, whether intramuscular or intravenous drip. Extended operations may require doses of 20 to 50 mcg per kilogram and a maintenance dose of 25 MCG up to the middle of the initial dose.
As a pain control tool, it can be drugs administered as a lozenge. The cleft should be placed between the face and the gums, which would allow the drug to absorb the mucosa of the mouth for 15 minutes. Standard initial will giveVKA for Fentanyl administered in this way is 200 mcg.
drugs can also be administered as a tablet that can dissolve sublingually or under the tongue, with an initial dose of 100 mcg. When the patient is transferred from the Pastinian to the tablet form of the drug, the translucent fentanyl dose is converted to 200 to 400 mcg to the initial sublingual dose of 100 mcg. However, the 600 or 800 mcg translum dose is converted into an initial dose of 200 mcg as a tablet. A dose of 1200 mcg or 1600 mcg used as lozenges is equivalent to the initial sublingual dose of 400 mcg. If one dose is not sufficient during treatment of episodic pain, after 30 minutes additional doses of the same force may be given after 30 minutes from the initial dose.
transdermal patches are sometimes used to ensure prolonged pain relief. However, they do not allow the patient to easily adjust the dosage to handle pain levels and side effects. In the absence of existing tolerance to opioid analgesics should be an initial dose for fentanYlová patch of 25 McG per hour every 72 hours.
Some medicines can also interact with fentanyl, potential effects or increase the occurrence of side effects. Nitrous oxide can cause cardiovascular depression when administered with fentanyl, while the central nervous system depressions (CNS) such as tranquilizers, barbiturates, general anesthetics and other narcotics may reduce the amount of drug needed to efficiency. Lower doses of both should be used when using these drugs.