What factors affect the sufficient dose of Letrozol?
Non -steroidal inhibitor of aromatase letrozol is a postoperative drug used to treat hormone reacting breast cancer. Sometimes known as Femara®, this drug works by blocking the production of estrogens interfering with the binding point on the aromatase molecules that are necessary for its production. Due to the low incidence of side effects, it is also occasionally used outside the brand to increase fertility in women's ovulation stimulation. When used to treat ovulation or for people with a dysfunctional liver, a significantly lower dose of letrozol is required. Other use off-tags for Letrozole include treatment of endometriosis, increasing the number of sperm in men, breast growth treatment in men and improving the development of children with growth disorders. Since 2011, however, there is no official dosage recommendation for these unapproved uses.
Letrozol is often used as a therapeutic supplement after five years of treatment with tamoxifen, especially in the treatment of early breast cancer in menopausal women. A dose of letrozole after this application is recommended for this applicationUZA 2.5 mg administered orally once a day. In 2011, there is no convincing research on how long this drug regime must continue to prevent relapse. If relapse occurs, the use of Letrozol should be used.
In cases where the diagnosis of breast cancer is a hormonal receptor positive, hormonal receptor unknown metastatic or locally advanced cancer can be referred to as first line therapy. The dose of 2.5 mg Letrozol administered orally once in 24 hours is considered standard for this application. It is also recommended in the treatment of advanced cancer in patients with disease progression after anti -nine therapy. If the tumor development is discovered, the use of this drug should be terminated.
Cirrhosis patients and severe hepatic dysfunction should be given a lower dose of letrozol, as the liver does not have to process the drug as effectively as in other patients. Insteadshould be given a dose of Letrozol 2.5 mg every other day. Hormone levels should then be carefully monitored to determine the effectiveness of the drug. However, no dosage adjustments are required in patients with reduced kidney function.
The use of this medicine carries some risks. Some of the potential side effects of Letrozol use are night sweat, heat pitfalls, muscle and joint pain, weakness and fatigue, nausea, vomiting, rashes, dizziness, limb swelling, constipation, diarrhea, loss of appetite or vaginal sectors. Other side effects include irritation, sleep disorder, upside down, breast pain, difficult or painful urination, cough and symptoms similar to flu and stomach pain. The use of Letrozol can affect bone density and increase the risk of osteoporosis. If chest pain or difficulty breathing devil, patients should stop using immediately because this may mean a more serious condition.