What factors affect a sufficient dose of losartan?

Also known as Hyzaar® and Cozaar®, Losartan is a drug mainly to treat high blood pressure in patients in which the use of an inhibitor of the converting angiotensin (ACE) is poorly tolerated. Unlike ACE inhibition of drugs, Losartan works by blocking angiotensin II sites, a receptor environment that increases vascular voltage during activation. Some of the use of losartan is to help reduce the progression of kidney disease, prevent stroke in patients with left ventricular hypertrophy and slowing neuropathy in patients with diabetes. In some patients with elevated blood pressure, lower doses of losartan may be used when the drug is combined with a low diuretic or blocker of the calcium channel thiazide. Other factors that may affect the dose size of the losartan to be used include the patient race, other medicines, liver health and kidney health.

In several studies, African American patients have shown the albums sitting sitting on drugs for inhibit ACE and angiotensin II, which youIt lines a significantly higher dose. Sometimes these drugs are used together with a physiologically active dose of thiazide diuretics. When it is added, the resistance is no longer observed and the recommendations for the dose of losartan are the same for patients of any race.

Losartan interacts with a number of different drugs, although many of these drugs may still be used along the drug. In particular, cholestyramines and colestipol can affect the intestinal ability to absorb drugs, which requires either a larger dose or preferably to separate the medication for several hours. Lithium can seriously interact with Losartan, although it may still be necessary to take both drugs. Despite the metabolic drug profile, there is no Any of serious drug interactions between losartan and digoxin or warfarin that require dosing.

6 Patients who are pregnant or who can get pregnant while taking losartan should be aware ofthat this medicine can cause damage or death of the fetus. Nursing mothers should also be aware that no research has been carried out to determine whether Losartan is going into breast milk.

It seems that returns are reduced when increasing the losartanese dose above 100 mg per day, without a statistically significant benefit proven in higher doses. Since the complete effects of the drug may not occur as late in six weeks after the start of the regime, the standard dose of losartan should not be increased to this point. Among the adults of one dose of 50 mgdenně should be used initially and evaluated again after six weeks. Maintenance doses of 25 to 100 mg can be used in one or two divided doses during the day. In patients with reduced liver function, the initial dose of losartan should be half to compensate for slower metabolism in the liver.