What factors affect a sufficient dose of nifedipine?
NIFEDIPIN, also sold under ProCardia®, Adalat®, Nifediac®, Nifedical® and Corpin®, dihydropyridine drugs used mainly in the treatment of angina, which is chest pain and high blood pressure. Like many other members of the Calcator Blocker Class Class, nifedipine is sometimes used to treat a wide range of other conditions such as esophageal spasticity, sometimes produced by cancer or tetanus, urban heart failure, migraine prevention, Raynaud syndrome, premature work and hypertrophic cardiopathy. The recommended initial dose of nifedipine varies according to the patient's age, treated condition, forms of the prescribed drug and liver condition. If, in addition to this medicine, the patient uses other medicines, interactions with the drug may need to adjust the standard dose.
When using this drug to treat high blood pressure in adults, the initial oral age of nifedipine 30 to 60 mg should be administered once a day. According to the manufacturer's recommendations, the dose can be increased once every one or two weeks up to MAXimal doses of 90 mg daily ADALAT® or 120 mg daily ProCardia®. IAS in 2011 was not approved for the treatment of high blood pressure in pediatric patients.
The standard initial dose of nifedipine used to prevent angina is 10 mg administered orally three times a day. The dose for widespread release tablets is between 30 mg and 60 mg administered daily. Nifedipine is not equivalent to nitroglycerin and should not be given to treat acute Angina attack. The dose can be carefully treated up every 7 to 14 days. The dose for the treatment of migraines is the same as the dose for the treatment of angina. Since nifedipine doses have not been demonstrated by any major clinical benefit, the increase in the standard initial dose is not recommended.
Initial oral dose of nifedipine 30 mg once daily in the form of Adalat (R) CC® or 30 mg to 60 mg in the form of Procardia XL® is recommended for the treatment of congestive heart failure. IncreaseDose is not recommended even daily maintenance doses. It has not been shown to cause significant clinical improvements at a standard dose.
In the administration of nifedipine to treat hypertrophic cardiomyopathy in pediatric patients, the appropriate dose of nifedipine is best calculated according to body weight. Within 24 hours, it should be administered between 0.6 mg and 0.9 mg per kilogram. The total daily dose should be divided into three or four separate doses administered during the day. The smallest possible effective dose should be administered because the side effects of nifedipine increase with dosage.
The most common side effects include headache, fatigue, dizzze, nausea, constipation, insomnia, rash, itching and joint or muscle pain. People who are pregnant or who can conceive should be informed that one of the side effects of nifedipine is a potential injury or fetal death. Animal studies have found that fetotoxic effects are dependent on the dose, with higher doses of dramatically habitThey sew the risk of fetal damage. The drug should only be administered during pregnancy if the health risk to the mother overshadows the risk to the fetus.
Despite the pharmacokinetics of nifedipine, it is not considered seriously with warfarin, digoxin, kumarin or chinidine, nor with most beta-adrenergic blocking substances, which are also known as beta-blockers. It is known that joint administration of nifedipine together with cimetidine produces higher levels of blood plasma of the latter drug, which is one of the more serious nifedipine drug interactions. Due to its cytochrome P450 3A4 (CYP3A4) enzyme inhibiting the activity of patients taking patients taking patient patients should completely refrain from consuming grapefruit or grapefruit juice because it can cause overdose. Other interactions of herbs and drugs include acarbose, nefazadone, drugs for narcotic pains such as Fentanyl, Wort St. John, Rifabutin, Rifampin, Rifapentin, Synthetic Antibiotics such as Klaritromycin, antifungal treatment such as drugs such as thycrolizing such as medications, some medication medicines that are used, what are medications that are used, such as medications that are used such as tykromycin such Such as Atazanavir, such as Atazavir, such as immunosuppressive drugs such as thecomycin like medicines such as Atazavir, such as Clarithromycin like Atazavir. High blood pressure and medicines for preliminary seizures such as phenobarbital.