What factors affect digoxin dosing?
The factors that affect digoxin dosing include weight and age, and most importantly, the level of the patient's blood in response to drug administration. The form of the drug is to determine how much it is used, another critical consideration. The renal cancellation continues to permanently require a lower level dosage. Some drugs also increase or lower serum digoxin levels and may require changes in the quantities used. This medicine is very useful in the right amount and deadly if used in excess. There are general instructions for dosing, but the individual reactions are so diverse that it should never be considered suitable for everyone. The only way to ensure that the patient does not develop long -lasting serum toxicity is regular testing of digoxin levels and therefore regulates the drug. This is especially important when starting therapy and continuing checks are required during the maintenance phase.
General digoxin dosing instructions are based on age and weight. Most patients begin a higher initial doseU, which is called load. It is important to mention that the form of a drug affects the specific amount. Lower doses are common with intravenous (IV) form of drug.
For example, for a two-year dose IV, it is calculated as 30-50 micrograms (MCG) per kilogram (kg) of weight. Then the maintenance dose is 7.5-12 mcg/kg. In contrast, oral suspension begins with a loading dose of 35-60 mcg/kg and maintenance dosage is 10-15 mcg/kg.
Adults usually take more digoxin than children with loading doses that can range from 400 to 750 mcg depending on the form of drug. IV, injections, tablets and liquid filled capsules are available for adults. Calls and injected or IV forms of drugs are usually taken in a lower microgram. The weight still affects the total amount, but also the serum concentration that helps to inform the doctor, whether the patient's reaction is within the therapeutic range. DiameterAn adult dose could be 125-500 mcg daily, depending on all these factors.
The abolition of the kidneys affects the dosage of digoxin because it limits how quickly the drug is cleaned from the body. The standard directive is to reduce the load dose by 50% for persons with kidney problems. The amount of maintenance is 25-75% normal. Creatinine levels are carefully evaluated to ensure that the kidney disease does not deteriorate. With these recommendations, most adults would probably use about 125 mcg a day.
Another influential factor in digoxin dosing is medicines that can react with it. Drug serum levels can be increased diuretics, heart drugs such as verapamil and Amiodarone and The Benzodiazepine, alprazolam. Conversely, some antibiotics, antacides and thyroid drugs can reduce serum digoxin levels and require an increased amount of its therapeutic range.