What is the first line treatment?

First line treatment refers to treatment or treatment regimen that is first used after the diagnosis of the clinical condition. Normally it has a treatment that has a majority of data on its efficacy and safety for this specific condition. Most often, the first line treatment includes medicines that have been a long time, because there is a lot of experience with them, both in practice and through clinical trials. Most countries have a national authority that oversees their health system, including standardized instructions for each clinical condition. These instructions are usually compiled by specific advice or organizations in each specialty operated by a group of specialists. For example, the US University of Cardiology (ACC) has set instructions for the treatment of myocardial infarction, which includes the treatment of the first line. This will include randomized controlled studies, drug pharmacology, pharmacoeconomics and therapy experience. Once they are taken into account all these and daLarge factors, the first -line treatment protocol will be set to have the best probability that it will be effective.

The first line treatment is only the selection of used medicines, but also the best non -ownership measures such as physiotherapy or psychotherapy. In most patients, the first line treatment should cause disease solving. However, it may not work in a small number and in these cases the treatment of the second and third lines may be required.

In some cases, for example in the treatment of human immunodeficiency virus, the first line treatment is replaced by the treatment of the second line if the patient's patient on the first line. The failure of the first line concerns the fact that the virus has become resistant to some or all medicines in mode. HIV is generally treated with triple therapy or three different drugs.

HIV is constantly replicating and changing and can cause mutations that make it resistant to some medicines. PraThe visible viral load is performed in patients with antiretrovira therapy and if this increases despite good adherence to drugs, it may be an indication of resistance. In these cases, they may be changed to the treatment of the second line, which will also contain at least three drugs, usually from different classes that will be active against HIV and return the viral load back down.