What is chlorochin resistance?

chloroquine is an antimalalarial drug. Doctors can usually cure people who are infected with parasites of malaria with different drugs, including this, but sometimes the parasite is immune to a certain drug. In the case of chlorochin resistance, the parasite seems to have developed in a way that prevents the drug from entering the parasitic cell. Chlorochin resistance is important for controlling malaria in the areas of the world where this disease exists.

Four different types of parasites cause malaria. These are Plasmodium Falciparum, P. Vivax, P. Malariae and p. Three of these species cause life -threatening diseases, but p.falciCum can potentially kill infected people. In the 1930s, a scientist with Bayer in Germany named Hans Andersag identified as a potentially useful chemical. In 1946 it became the treatment of malaria. Chlorquin has therefore been used for decades.

These types of drugs are always tested to target one or more specific fUnktí parasite. In the case of chlorochine, the objectives seem to be genetic material parasite and storage and detoxification of certain products. With all these events together with the drug can kill the parasite.

Although working on parasite, but chlorochine must get into the cell plasmodium . Each individual cell parasite has a cellular structure and one of the properties of the cell is a vacuola of food, a closed area where the food that the cells consumes breaks. It is these food vacuums that collect chlorochin molecules and the effects of the drug. Scientists believe that the drug prevents cells from collecting toxic waste products of food and their harmless. The cell then dies from toxic molecules inside.

Patients with malaria over the years have received chlorochin and other antimalars. The parasite, which was originally sensitive to the drug, has developed chlorine resistance in response to its effects. The resistance seems to beIt is a genetic origin and is caused by certain parasites that have had a change in the treatment of genetic material that survives chloroquine. These new versions of parasites then became a predominant type in areas where chloroquine treatment killed all sensitive plasmodia . The dangerous form of malaria, plasmodium Falciparum is resistant to the drug in many areas and p. vivax can also be resistant.

One explanation for chlorochin resistance is that the parasite genes produced new versions of the transporter molecules. These transporter molecules help to move substances such as medicines across membranes. One of the theories about chlorochin resistance is that new versions of transporters can send chlorochin molecules back from the vacuole to reduce possible damage to parasite. However, the exact way in which the plasmodium resists the effects of the drug is not well known.