What is the resistance to clopidogrel?

Clopidogrel is a medicine that is often used to treat heart attacks in combination with aspirin. It acts by blocking certain receptors on blood particles called plates, so it is less likely that they will form clots in coronary arteries that give the heart. In some people, clopidogrel does not seem to work, and this phenomenon is known as clopidogrel resistance. Although the term resistance to clopidogrel is as if referring to one particular mechanism, there are really several reasons why the drug may not work for the individual. Resistance differs from therapy failure, where the drug has created the right reaction in the body, but the patient disease is repeated due to other factors.

because it helps prevent the formation of blood clots, clopidogrel is given to people who had a heart attack or stroke to prevent repetition. It can be administered in combination with aspirin according to the opening procedures of blocked arteries. They could include balloon angioplasty where abalon is inflatednecessary inside the artery and stent where the tube is inserted to open an open blood vessel. Patients with clopidogrel resistance may have an increased risk of complications after these operations. Other use of clopidogrel is the treatment of chest pain, which is associated with heart attacks and a condition known as angina, where the heart blood supply is insufficient.

Before clopidogrel can manifest itself in the body, it must be absorbed from the intestine into the bloodstream. Furthermore, it must be transformed into its active form of enzymes in the liver. If patients have a condition that prevents proper drug absorption, this could lead to resistance to clopidogrel. In some patients, the required liver enzymes may not function normally, so less clopidogrel is converted into an active form, making the drug less effective. Drug interactions to clopidogrel may occur when they turn the drugs used at the same time use the same enzymes, leading to lower DFlopidogrel's active form.

In some cases, clopidogrel resistance can increase the dose of clopidogrel, but a higher dose can also lead to side effects. The side effects of clopidogrel may include joint pain, abnormal bleeding, diarrhea and abdominal discomfort. Research continues to resistance to clopidogrel and later, more effective treatment is examined. Genetic testing could also detect which patients have abnormally functioning versions of liver enzymes responsible for the conversion of clopidogrel.