What is the connection between Vankomycin and Redman syndrome?
Vankomycin is an antibiotic that kills various bacterial pathogens. A possible side effect of the drug is a collection of symptoms called Redman's syndrome due to redness and rash to which it usually occurs. This problem is the hypersensitive allergic reaction that occurs because antibiotics interferes into the cells of the immune system. However, two main side effects of the immune system are possible for vancomycin. More serious is anaphylaxis, which can cause breathing problems due to swollen facial and cervical tissues. In the case of vankomycin and Redman syndrome, symptoms may be mild and do not endanger life.
Problems occur with vancomycin and Redman syndrome when the doctor infuses the antibiotic into the patient's vein. The symptoms of vancomycin and Redman syndrome are the most obvious on the skin. Red itchy rash develops, but it can be as insignificant as slight redness of the skin. Dizziness and flu and headaches may also occur. Some people suffering problems caused by syndromeEm Vankomycin and Redman also have a decrease in blood pressure or chest pain.
Some components of the immune system are responsible for the cause of these symptoms. Cells called mast cells and basophils contain storage granules of substances called histamine. Histamine is one of the molecules of the signal of the immune system and plays a role in the development of inflammation. Vankomycin works on these cells to release histamine stored inside.
abnormally high histamine levels in circulation then causes symptoms associated with Redman syndrome. Rash and itching represents unnecessary activation of the immune system. In fact, doctors can give patients antihistamines prior to vancomycin treatment in anticipation of this activation of the immune system.
Only some people develop Redman's syndrome, while others don't. Scientists think it is caused by genetic differences between patients. For example, some enzymes in the bodiesE naturally break down histamine. This role is performed by two enzymes, which are histamine n-methyltraserase and diamine oxidase. Different people produce slightly different versions of these enzymes that could have different efficiency and which may be one explanation for the absence of Redman's syndrome in some people and its development in others.
as well as potential genetic causes, other antibiotics can work in conjunction with vancomycin and increase the risk of Redman's syndrome. Examples of these antibiotics, which the doctor can administer with vancomycin include ciprofloxacin and amphotericinb. Some painkillers and muscle relaxation may also increase the likelihood of syndrome.