What is the difference between cisplatin and carboppatin?

The main differences between cisplatin and carbopplatin include molecular structure, dosage and side effects. Both intravenous chemotherapeutic products contain platinum, but have slightly different molecular structures. While doctors can use cisplatin and carbopplatin for lung or ovarian cancer, cisplatin is also used to treat bladder and testicular cancer. In many cases, the common dose of carbopplatin is up to three times higher than the cisplatin, but the body eliminates the carbopplatin faster. The cisplatin contains ammonia molecules on one side of the central platinum molecule and chloride molecules on the other. Carbopplatin has ammonia molecules on one side of the platinum molecule and an oxygen complex on the other side. Both drugs interact with deoxyribonucleic acid (DNA) healthy and cancer cells, inhibiting reproduction and general cell function.

oncologists determine the doses of milligrams of cisplatins and carbopplatins based on square meters of body surface. SubstituteCancer treatment of testicles generally receive cisplatin dosing 20 mg/m

2 body surface daily for five days. Patients with ovarian cancer receive 75 to 100 mg/m 2 once a month, and patients with bladder cancer receive 50 to 75 mg/m

2 every three to four weeks. Patients must hydrate with one to two liters of fluid before administration of both drugs. Patients with ovarian cancer usually receive carbopplatin at doses up to 300 mg/m

2

once a month.

Carbopplatin dosing can also be based on creatinine clearance or kidney function. Doctors sometimes treat patients with ovarian cancer by combining carbopplatins and cisplatins or cyclophosphamide. Although cisplatin and carbopplatin have similar properties and structures, the body eliminates them differently. The kidneys eliminate up to 40% cisplatin within 24 hours. Studies indicate that higher solubility toArboBlatins allows the body to eliminate up to 71% in 24 hours.

After administration, platinum in both drugs is released from the surrounding molecules in the compound and binds to plasma proteins remaining in cells for up to 180 days. Both drugs cause side effects, but the effects of each differ. Reactions to cisplatin include the central nervous system and peripheral toxicity that create symptoms that could include muscle spasms, painful muscle contractions and seizures. Symptoms may occur after an initial dose or four to seven months of treatment. Drugs can affect the eyes and cause blurred vision, changes in color perception or blindness due to inflammation and swelling, but disorders of visual disappearance after treatment.

cisplatin and carbopplatin can cause reduction of electrolyte levels in the blood, but some studies suggest that patients receiving cisplatin experience it more often. Electrolytes generally influenced by drugs include calcium, magnesium, phosphorus, potassium and sodium. Cisplatin mIt can increase blood uric acid levels, requires patients to receive alopurinol drugs. While both cisplatin and carbopplatin cause bone marrow suppression, they affect the life and production of white blood cells and plates, the condition is easier to administer carbopplatin.