What is warfarin resistance?
Warfarin resistance occurs when patients need unusually high doses of drug to achieve the desired therapeutic international normalized ratio (INR). Most individuals who use this medicine do not experience this condition and after the start of the period will have regular blood values of INR. Failure to follow drugs according to the instructions is often identified as resistance to warfarin, although it is inaccurate. Other times, the condition is legitimately found due to a diet that has an extremely high content of vitamin K, drugs that reduce Warfarin's efficacy or malabsorption of drugs. Several studies have also identified a gene that, when disrupted, disrupts how well this anti-cut drug works.
Although the dose of warfarin varies greatly in individuals, the prescribed amount for most patients falls within the expected range. Usually there are 10-15 milligrams (mg) a day and many patients take much less to achieve therapeutic INR. Sometimes warfarin resistance is defined as the need to take more than 20 mg denine drug to achieve the desired INR. Alternatively, this term can be more freely defined as the need to take doses that far exceed the normal range for patients.
Most doctors feel the most common cause of warfarin resistance is psychological or social resistance. In other words, it is the inability to take medication according to the instructions. If the instructions on how to use the drug are not adhered to, INR predicts the therapeutic range and the dose usually increases. This is a danger if the patient suddenly becomes compatible with treatment after a huge increase in the drug, as he could start taking much more warfarin than safe.
The actual resistance to warfarin is caused by other factors. For example, the medicine inhibits vitamin K K K Raise to reduce blood clotting, but people may have adequate and consistent food intake as a leaf green vegetable that contains it. If the meals areAnd consisting of only a huge amount of vitamin K food, Warfarin does not have to be able to work adequately. Extreme diets such as an all-spinach diet are most likely to pose this danger.
In addition, numerous drugs reduce the strength and efficacy of warfarin. It is important to observe that many people who require this anti-cure drug can have many other regulations for related conditions. Finding a combination of medicine that does not cause warfarin resistance can be challenging.Other reactions that affect the patient's resistance to warfarin are found in the gastrointestinal tract, or are based on errors in a particular gene. If conditions such as colitis disrupt absorption, the patient may need very high doses of warfarin to achieve therapeutic INR. Studies have also found that defective genes in the multiprotein complex of vitamin K epoxy reductase (ink) may result in warfarin resistance, making it difficult or impossible and impossible anddeciduously reduce the levels of vitamin K.
Warfarin resistance is a problem because it can prolong the time when patients take to achieve a medically recommended INR that reduces the likelihood of blood clots. Furthermore, it is not always safe to use a large amount of medicine. One solution to the problem is to prescribe warfarin another anticoagulant such as aspirin. This can eliminate the need to prescribe warfarin in very high doses and can reduce the danger remaining in the sub-therapeutic range of the INR.