What is pyridoxal phosphate?

pyridoxal phosphate (plp) is an active form of vitamin B6. It is also known as pyridoxal-5-phosphate or P5P. This phosphate is a combination of pyridoxic, pyridoxamine and pyridoxine - all of these are natural forms of vitamin B6. PLP is not a protein, but acts as a cupboard for a number of enzymes and protein groups. A common factor, also known as a prosthetic group, is a chemical compound that is tied to protein and is necessary for the functioning of the protein. Transamination is a key process in creating irrelevant amino acids and would not be possible without PLP. This reaction is considered kinetically perfect, which means that every time this can happen, yes. These types of reactions are unusual and some display kinetics that are faster than diffusion speed, which should be chemically impossible. Speculation on the mechanism that works so efficiently includes dipolar electrical fields and quantum mechanical tunneling of protons.

Vitamin B6 is part of a group of vitamins-complex B and is soluble in water. He was isolated for the first time at the age of 30 for rats undergoing nutrition studies. In 1934, the Hungarian doctor Paul Gyorgy found that the same compound was able to alleviate skin diseases in rats and named it with vitamin B6. Over the next ten years, vitamin B6 was isolated in rice bran; All three precursor forms of pyridoxal phosphate were discovered; and Vitamin B6 was named Pyridoxin.

PLP is essential in a number of enzymatic activities. The British enzyme Commission (EC) has documented more than 140 enzymatic reactions that depend on the functioning of pyridoxal phosphate. This equals approximately 4% of all known enzyme reactions.

There are seven known varietamine B6s, but only plp is metabolically active. However, all of them can be converted into each other, except for 4-pyridoxic acid. Once this version of the vitamin is created, it is excreted in the MOwhose.

pyridoxal phosphate is also involved in macronutrient metabolism, neurotransmitter synthesis and gene expression. In addition, it also plays a role in gluconeogenesis (GNG), which is one of the two processes that the human body uses to maintain glucose levels in the body. GNG is a metabolic pathway and the reaction of plp in the body provides the necessary amino acids for the path to create glucose. This form of vitamin B6 is one of the most functional and most used in the human body.