What is the cloak zone?

The cloak zone is part of the lymphatic cortex that surrounds the germ center of the lymph node. The circle of small lymphocytes consists of a cloak zone or corona lymph nodes. Germinal centers in the lymph nodes are the location of proliferation, differentiation and mutation of ripe centroblasts or B-lymphocytes necessary for a properly functioning immune system. The humoral immune response (HIR) begins under the cloak zone in the germ center of the lymph node. B-cells in the cloak zone are transformed into antibody plasma cells or memory cells after stimulation by secondary antigen, such as cells found on the surfaces of many microbes.

The benign state that causes the growth of the cloak zone is called Castleman's disease, which is also called angiofollicular hyperplasia. One variety of state is unicentre, which means that the zone of the tire of a single lymph node has a non -lawyer growth. Most doctors recommend surgical removal of the lymph node and subsequent appointment to ensure thatdid not renew the growth.

6 A person with a multicentric castleman's disease (MCD) may have other basic conditions such as immunodeficiency syndrome (AIDS), human immunodeficiency virus (HIV) or Kaposi's sarcoma. Although there is no standard MCD treatment, some patients respond well to corticosteroid therapy and chemotherapy.

One of the most common types of Non-Hodgkin's lymphoma, cancer called the lymphoma of the mantle cells (MCL), develops in a coat of lymph nodes. Lymphocytic cells in the cloak zone begin to divide before they are ripe. These young cells Continue replicate and start to accumulate in the lymphatic system. In the end, the whole immune response is threatened.

Most people diagnosed with MCL are men who are at least 60 years old. Unexplained weight loss, night sweating, persistent fever and swollen lymph nodes are often the first symptoms that a personnotices. The growth of lymph nodes can feel like a small marble and is usually located on the neck, either in the armpit or on each side of the groin.

Diagnostic tests for MCL include scanning computed tomography (CT) chest, abdomen and pelvic areas. Blood and bone marrow are often tested for the presence of cancer cells. The diagnosis occurs after the lymph node is surgically removed and examined in the laboratory. Treatment usually includes chemotherapy, radioimunotherapy, immune therapy and the use of biological substances to destroy cancer. Another method of treatment involves chemotherapy, then overall body radiation (TBI) to destroy the destroying system, followed by transplantation of stem cells to rebuild the immune system.