What is a sentinel lymph node?
Although it could remain hypothetical and elusive, the idea of sentinel lymph nodes as the first place where it must go through metastasizing cancer cell to infect other places of the body, significantly affect the diagnosis and treatment of the disease. When spreading, the mortality of cancer and the primary way for many types of cancer is a vascular lymphatic system. Most often, the first free pathogenic cell will be captured by the first lymph node to meet. The identification and treatment of this first small node has the potential to arrest the tumor ability to spread.
The human lymphatic system is a network of blood vessels, unlike the circulatory system that spreads throughout the body. It uses and transposes lymphocytes and phagocytes, cells that specialize in finding and neutralizing foreign substances, including cellular residues and extraterrestrial organisms. There are globular cavities called lymph nodes along the net and filter lymphthecutin as a terminal trap for unwelcome attackers. In the throat, armpitsAnd the weaknesses are their subdermal clusters, but the nodes are distributed in the vascular lymphatic system. It is a basic system of functional body design for pathogenic immunity.
When cancer is discovered, the prevailing question is whether it has metastasis or spread to other places in the body. If the primary tumor is isolated, it can be surgically removed and lead to a favorable prognosis for the patient. At the same time, however, the treatment of multiple tumors and control of their spread requires different, much more difficult and aggressive therapy. Okology, study and treatment of cancer has definitely found that many common cancers can and quickly migrate to a secondary place through the lymphatic system. This extent, for example with breast cancer, will not affect tissue, which will be surgically removed, its closest lymph nodes can also be preventively removed to prevent cancer.
The concept of sentinel lymph nodes was conceived in the 90s as an alternative to radical lymphadenectomy. Given the assumptions that metastasizing cancer cells will try to infiltrate the lymphatic system and that lymph nodes in it act as guard houses for potential pathogens. The conclusions that follow are that if cancer could be the nearest closest place of infiltration, it would lead to a lymph node that can be checked or monitored for its presence. Not only would such a sentinel lymphatic node be a significant diagnostic pompous to the critical issue of metastases, but it could dictate the course and prognosis of treatment.
Although in the end it remains theoretical, the search for sentinel lymph nodes transformed oncology with advanced surgical procedures. In the biopsy of the sentinel lymph nodes, for testing, radioactive substance with a very short half -life is injected near the tumor. The crumbling substance that has been occupied by the lymphatic system is easilyFollowed and mapped by a device called scintigraph that reveals the path of vessels and nodes. This is followed by a second dye injection to make lymph nodes visible so that the surgeon can dissect the first in accordance for immediate laboratory analysis for the presence of cancer cells. It would seem reasonably that it is a sentinel lymph node, and if the biopsy returns a negative result, it may be a high indicator that the tumor has not been metastasized and can be treated with less aggressive therapies.
questions are likely to persist. There may be more sentinel nodes and cancer can spread by means other than the lymphatic system. False negative test results from small biopsy samples may not be completely eliminated. It seems impractical to follow the positive results of Lymphyuzel tests to more and more until the Sentinel terminal is found. However, this basic clinical frameworky.