What are mice antibodies?
mice antibodies, often also referred to as monoclonal antibodies, are immunoglobulin molecules that are capable of linking to a specific antigen space that can stimulate natural production of antibodies in human immune systems. Antibodies are used by the immune system to recognize the presence of foreign material, such as viruses and bacteria, and target it to destruction. The production of monoclonal mice antibodies first began in 1975, when scientists Niels K. Jerne, Georges J.F. Kohler and Cesar Milstein discovered a method for generating specific antibodies from mouse tissue known as mouse host B cell. Scientists have been able to produce cellular lines that are still used as a form of therapy to treat many diseases, including cancer, and therefore won the Nobel Prize in Physiology or Medicine in 1984.For honey, for honey, for honey, for honey, for honey, for honey, for honey, for honey, for honey, for honey, for honey, for honey.
The production of antibodies using mice antibodies was a breakthrough for medical research and disease treatment. It has been shown that these antibodies are more abundant and uniform than the natural antibodies of man and were therefore considered a useful way to strengthen the ability of the immune system to fight the disease. Research antibodies are now produced for a number of uses, including measuring serum drugs, identification of infectious substances, writing blood and tissues, for classifying various forms of leukemia and lymphomas and more. The actual antibodies also began to be produced from close relatives of mice, including hamsters and rats, as well as other species such as goats and sheep.
Since the therapeutic use of mice antibodies has expanded, problems began to appear. Initial treatment in patientThe NTs were well tolerated, but as the subsequent treatment continued, the human body began to indicate an immune response to the mouse proteins by generating human antibodies against them. This answer is known as human anti-two antibody (Hama) and can completely neutralize the beneficial effect of treatment with mice antibodies and also causes allergic responses in some patients. In order to minimize side effects, recombinant DNA processes have been used to replace up to 70% of mice protein with human protein sequence. This process of improvement was led by Greg Winter in 1986 at the Cambridge University in the UK and reduced the total amount of original mouse tissue in antibody to 5-10%, which was much better tolerated as therapy.
Recent technology now allows genetic engineering 100% of human antibodies for research and therapeutic treatment. Also the most effective way of creating a large number of mice antibodies in the laboratory, the process of Freund Complete Adjuvans (FCA), created painful inflammationLive lesion of mice and has become a heated goal of protests by animal rights such as American American American anti-life society. This subsequently led to American federal organizations such as the National Institutes of Health (NIH), and European nations such as Switzerland and Germany, which requires in vitro production of mice to be used in the use of adult laboratory animals.