What are acetylcholinesterase inhibitors?
Acetylcholinesterase inhibitors, also known as anticolinesterase, are drugs that slow down the effect of cholinesterase or acetylcholinesterase. It is an enzyme involved in the nerve processes in the brain. Cholinesterase changes acetylcholine into choline and acetic acid in the brain process in which cholinergic neurons go from active to rest. They work by increasing the availability of cholinesterase to the brain. Acetylcholinesterase inhibitors are also used to reverse the paralysis caused by the drug during surgery and for the treatment of myasthenia gravis and glaucoma. Although it has not yet been approved by US food and drug administration (FDA), acetylcholinesterase inhibitors have been evaluated for use in vascular dementics, dementia with Lewy bodies and Parkinson's induced dementia. This type of drug is also used in pesticides and biochemical cylinders. Usually these side effects are smaller and appear to go through the start of the drug within a few days of the start of the drug. The drug is neurotoxin and large doses can beFatal, so careful monitoring of the patient is necessary.
Research suggests that acetylcholinesterase inhibitors work best when they are prescribed for the early phase of Alzheimer's disease, and although they are not treatment, they can prolong the time between the onset of Alzheimer's disease and the need for institutionalization. This allows patients with Alzheimer more time at home with their loved ones and also saves money by reducing the need for full -time care by improving behavior and thinking ability. Studies are still ongoing to evaluate the effect on patients with a traveled Alzheimer's.
It is recommended that a patient taking inhibitors of acetylcholinesterase be evaluated four to six weeks after the start of the drug to assess the improvement of symptoms and monitor side effects. Then they should be evaluated every three months after. Klinické údaje naznačují, že léčba tímto lékem je po jednom roce méně účinná a léčiva se v této době obvykle zaIt builds, although some patients continue to show improvement. Patients should usually be evaluated in a case -by -case case to see if this therapy is fine for them.