What are P450 inhibitors?

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P450 concerns the family of metabolic proteins called Cytochrome P450 enzymes; They are responsible for decomposing drugs inside the body. P450 inhibitors slow or stop the chemical effect of the P450 enzyme, usually by binding with the enzyme before it can do their work. It is known that some drugs are P450 inhibitors, but some foods can also inhibit these enzymes. In some cases, it is useful to use P450 enzymes effectively because they break some drugs before the drug can work. In other cases, drugs and foods should be avoided that inhibits the function of enzymes to prevent the drugs to break down quickly and do not build in the body. These enzymes begin with the process of decomposing many different substances that could become toxic if they were not excreted in urine or bile. Glass include medicines, illegal drugs, steroid hormones and other organic molecules.

a wide range of drugs acts as inHibitors P450. This inhibition - along with the opposite effect, induction - is responsible for most of the problems with the drug interaction and can cause some drugs to be built at toxic levels in the body. Many antidepressants, such as Prozac, Zoloft and Luvox, are inhibitors of some P450 enzymes along with tagemet, Cipro, Benadryl and a long list of other drugs. Consumption of grapefruit, grapefruit juice, star meat, watercress and even the use of tobacco products also inhibits these enzymes.

Some medicines are no longer used in the United States due to life -threatening side effects caused by interaction with other drugs that are P450 inhibitors. Examples include Seldane, Hismanal, Propulside. Another medicine, a position, byluknation, because it is in itself a strong inhibitor P450, which dangerously responded with some heart drugs.

One of the important points is that some drugs are less effective in that they metabolize faster while other drugs are truly effectiveand. Drugs already in chemical form, which is biologically active, also do not consider symptoms if there is a high activity of the cytochrome P450. They can work better when used with P450 inhibitors. Other medicines are used in inactive form and are activated by the first stage of decay. These drugs may not work well if the patient also takes the cytochrome inhibitor P450.